Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis. (Q48298601)

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24 December 2019

title

Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis (English)

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24 December 2019

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Subhas C Biswas

1

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24 December 2019

Yijie Shi

2

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24 December 2019

Jean-Paul G Vonsattel

3

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24 December 2019

Conrad L Leung

4

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24 December 2019

Carol M Troy

5

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24 December 2019

Lloyd A Greene

6

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24 December 2019

language of work or name

English

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publication date

1 January 2007

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24 December 2019

published in

Journal of Neuroscience

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24 December 2019

volume

27

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24 December 2019

page(s)

893-900

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24 December 2019

issue

4

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Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

24 December 2019

cites work

1 reference

12 December 2020

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

12 December 2020

Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

1 reference

12 December 2020

Caspase-2 mediates neuronal cell death induced by beta-amyloid

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12 December 2020

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.

1 reference

12 December 2020

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

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12 December 2020

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

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12 December 2020

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

12 December 2020

Expression of apoptosis related proteins in brains of patients with Alzheimer's disease.

1 reference

12 December 2020

Regulation of neuronal survival and death by E2F-dependent gene repression and derepression.

1 reference

12 December 2020

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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12 December 2020

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

12 December 2020

Hyperphosphorylation of the retinoblastoma gene product and altered subcellular distribution of E2F-1 during Alzheimer's disease and amyotrophic lateral sclerosis.

1 reference

12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

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12 December 2020

Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation

1 reference

12 December 2020

Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

1 reference

12 December 2020

Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.

1 reference

12 December 2020

Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons

1 reference

12 December 2020

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

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12 December 2020

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

1 reference

12 December 2020

Cell cycle molecules and vertebrate neuron death: E2F at the hub.

1 reference

12 December 2020

B-myb and C-myb play required roles in neuronal apoptosis evoked by nerve growth factor deprivation and DNA damage

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12 December 2020

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

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12 December 2020

Divide and die: cell cycle events as triggers of nerve cell death.

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12 December 2020

Neuronal structure is altered by amyloid plaques

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12 December 2020

Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

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12 December 2020

Regulation of neuron survival and death by p130 and associated chromatin modifiers

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12 December 2020

BH3-only proteins: key regulators of neuronal apoptosis

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12 December 2020

The cell cycle in Alzheimer disease: a unique target for neuropharmacology

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12 December 2020

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease

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12 December 2020

Bim is a direct target of a neuronal E2F-dependent apoptotic pathway.

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12 December 2020

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12 December 2020

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels

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12 December 2020

The neuropathology of Alzheimer's disease.

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12 December 2020

An improved approach to prepare human brains for research

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12 December 2020

Possible role of apoptosis in Alzheimer's disease.

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12 December 2020

Mechanisms of neuronal degeneration in Alzheimer's disease

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12 December 2020

Mechanisms of neuronal death in Alzheimer's disease

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12 December 2020

Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

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12 December 2020

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

1 reference

12 December 2020

Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents

1 reference

12 December 2020

10.1523/JNEUROSCI.3524-06.2007

Identifiers

DOI

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