PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. (Q34044630)

30 July 2017

PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim. (English)

1 reference

30 July 2017

0 references

1 reference

Esteban N Gurzov

4

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Izortze Santin

object named as

Izortze Santin

1

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Lorella Marselli

object named as

Lorella Marselli

5

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Piero Marchetti

object named as

Piero Marchetti

6

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author name string

Fabrice Moore

2

1 reference

30 July 2017

Maikel L Colli

3

1 reference

30 July 2017

Decio L Eizirik

7

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30 July 2017

language of work or name

English

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publication date

7 October 2011

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30 July 2017

10

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inferred from page(s)

published in

Diabetes

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30 July 2017

60

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30 July 2017

3279-3288

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30 July 2017

12

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

30 July 2017

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance

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A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease

28 July 2018

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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

28 July 2018

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STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation

28 July 2018

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Enterovirus RNA in blood is linked to the development of type 1 diabetes

28 July 2018

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Enterovirus infection induces cytokine and chemokine expression in insulin-producing cells.

28 July 2018

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Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine

28 July 2018

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p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

28 July 2018

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Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells

28 July 2018

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MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.

28 July 2018

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Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2

28 July 2018

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Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

28 July 2018

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Genetics of type 1A diabetes

28 July 2018

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The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

28 July 2018

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PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis

28 July 2018

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T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

28 July 2018

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Shared and distinct genetic variants in type 1 diabetes and celiac disease

28 July 2018

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Viral trigger for type 1 diabetes: pros and cons

28 July 2018

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Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice

28 July 2018

1 reference

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Multisite phosphorylation regulates Bim stability and apoptotic activity

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

The role for endoplasmic reticulum stress in diabetes mellitus

28 July 2018

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STAT activation and differential complex formation dictate selectivity of interferon responses

28 July 2018

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Environmental factors in the development of Type 1 diabetes

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

PTP1B and TC-PTP: novel roles in immune-cell signaling

28 July 2018

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A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

The role of BH3-only proteins in the immune system

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis.

28 July 2018

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T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Protein tyrosine phosphatase non-receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Interplay between PTPN22 C1858T polymorphism and cow's milk formula exposure in type 1 diabetes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Genomewide association studies and human disease

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Toll-like receptor 3 and STAT-1 contribute to double-stranded RNA+ interferon-gamma-induced apoptosis in primary pancreatic beta-cells

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3219938

Increased level of interferon-alpha in blood of patients with insulin-dependent diabetes mellitus: relationship with coxsackievirus B infection

28 October 2018

1 reference

12 December 2020

Interferon expression in the pancreases of patients with type I diabetes

1 reference

12 December 2020

Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes

1 reference

12 December 2020

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation

1 reference

12 December 2020

p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65

1 reference

12 December 2020

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells

1 reference

12 December 2020

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis

1 reference

12 December 2020

Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis

1 reference

12 December 2020

A polymorphism in PTPN2 gene is associated with an earlier onset of type 1 diabetes

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB11-0758

1 reference

release_pka335yah5bozaomfzlsk36hay

30 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pka335yah5bozaomfzlsk36hay

24 November 2022

mapped directly with Wikidata item

PMCID

3219938

1 reference

30 July 2017

1 reference