Animal models of Alzheimer's disease and evaluation of anti-dementia drugs (Q34126136)

31 July 2017

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title

Animal models of Alzheimer's disease and evaluation of anti-dementia drugs (English)

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31 July 2017

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Yamada K

1

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PubMed ID

11150591

31 July 2017

Nabeshima T

series ordinal

2

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PubMed ID

11150591

31 July 2017

language of work or name

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1 November 2000

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Pharmacology & Therapeutics

31 July 2017

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31 July 2017

88

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31 July 2017

2

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31 July 2017

93-113

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Fibrillogenesis of beta-amyloid.

31 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-amyloid peptides as direct cholinergic neuromodulators: a missing link?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Vitamin E protects nerve cells from amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Simulation of cortical cholinergic deficits--a novel experimental approach to study pathogenetic aspects of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neuron loss in APP transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Roles for proteolysis and trafficking in notch maturation and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The neurochemical and behavioral effects of beta-amyloid peptide(25-35)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Implants containing beta-amyloid protein are not neurotoxic to young and old rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Block of LTP in rat hippocampus in vivo by beta-amyloid precursor protein fragments.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Association between Alzheimer's disease and the NOS3 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Topography of a binding site for small amnestic peptides deduced from structure-activity studies: relation to amnestic effect of amyloid beta protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Apoptosis mediated neurotoxicity induced by chronic application of beta amyloid fragment 25-35.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effects of repeated administration of propentofylline on memory impairment produced by basal forebrain lesion in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Lack of Alzheimer pathology after beta-amyloid protein injections in rat brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Down patients: extracellular preamyloid deposits precede neuritic degeneration and senile plaques.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

From molecular structure to Alzheimer therapy

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https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Differential effects of amyloid peptides beta-(1-40) and beta-(25-35) injections into the rat nucleus basalis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer's disease: its proteins and genes

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https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Progress toward valid transgenic mouse models for Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer's disease: the amyloid cascade hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Propionyl-IIGL tetrapeptide antagonizes beta-amyloid excitotoxicity in rat nucleus basalis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Transgenic mouse brain histopathology resembles early Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Dysfunction of cholinergic and dopaminergic neuronal systems in beta-amyloid protein--infused rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effects of metrifonate on memory impairment and cholinergic dysfunction in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Impairments of long-term potentiation in hippocampal slices of beta-amyloid-infused rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase Mos.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Cerebrospinal fluid A beta42 is increased early in sporadic Alzheimer's disease and declines with disease progression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Regulation of amyloid precursor protein secretion by glutamate receptors in human Ntera 2 neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid beta-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Advances in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effects of vinconate on spatial learning impairments induced by medial septal lesion in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Structural model for the beta-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A putative tetrapeptide antagonist prevents beta-amyloid-induced long-term elevation of [Ca2+]i in rat astrocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Tau in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A 12-month, randomized, placebo-controlled trial of propentofylline (HWA 285) in patients with dementia according to DSM III-R. The European Propentofylline Study Group.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Oxidative stress hypothesis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Sigma1 (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Present imperfect: a critical review of animal models of the mnemonic impairments in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effects of an exogenous beta-amyloid peptide on retention for spatial learning.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Activation of microglial cells by beta-amyloid protein and interferon-gamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Interaction of the anthracycline 4'-iodo-4'-deoxydoxorubicin with amyloid fibrils: inhibition of amyloidogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Regulation of amyloid precursor protein cleavage.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Cholesterol-dependent Generation of a Seeding Amyloid β-Protein in Cell Culture

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Ibotenate Lesions of Hippocampus and/or Subiculum: Dissociating Components of Allocentric Spatial Learning.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Using okadaic acid as a tool for the in vivo induction of hyperphosphorylated tau.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Memory impairment and neuronal dysfunction induced by beta-amyloid protein in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor-antibody.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Oral administration of NGF synthesis stimulators recovers reduced brain NGF content in aged rats and cognitive dysfunction in basal-forebrain-lesioned rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Indomethacin reverses the microglial response to amyloid beta-protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer's disease: a re-examination of the amyloid hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Memory impairment and neural dysfunction after continuous infusion of anti-nerve growth factor antibody into the septum in adult rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

beta-Amyloid protein-induced Alzheimer's disease animal model.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Oral administration of idebenone induces nerve growth factor in the brain and improves learning and memory in basal forebrain-lesioned rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

One of the antigenic determinants of paired helical filaments is related to tau protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Naftidrofuryl oxalate, nootropic effects on the scopolamine- and the basal forebrain lesion-induced amnesia in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Alzheimer's disease: genetic studies and transgenic models

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Formation of beta-amyloid protein deposits in brains of transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The Alzheimer diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurodegeneration and gliosis in transgenic mice overexpressing a carboxy-terminal fragment of Alzheimer amyloid-beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid peptides are toxic via a common oxidative mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

1 reference

7 January 2021

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Bilateral injections of amyloid-beta 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Tau protein pathology in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Transgenic animals in Alzheimer's disease research.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

NC-1900, an active fragment analog of arginine vasopressin, improves learning and memory deficits induced by beta-amyloid protein in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Presence of soluble amyloid beta-peptide precedes amyloid plaque formation in Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Arrest of beta-amyloid fibril formation by a pentapeptide ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Acute or chronic administration of okadaic acid to rats induces brain damage rather than Alzheimer-like neuropathology.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Familial Alzheimer's disease: oxidative stress, beta-amyloid, presenilins, and cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Solvent effects on beta protein toxicity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Time course of cholinergic and monoaminergic changes in rat brain after immunolesioning with 192 IgG-saporin.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

192 immunoglobulin G-saporin produces graded behavioral and biochemical changes accompanying the loss of cholinergic neurons of the basal forebrain and cerebellar Purkinje cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Ca2+ channel blockers attenuate beta-amyloid peptide toxicity to cortical neurons in culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neural lesioning with ribosome-inactivating proteins: suicide transport and immunolesioning

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Immunolesioning: selective destruction of neurons using immunotoxin to rat NGF receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Cholinergic strategies for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

beta-Amyloid-(1-40) increases long-term potentiation in rat hippocampus in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Impairment of active avoidance response in rats with continuous infusion of quinolinic acid into the lateral ventricle

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Changes in ciliary neurotrophic factor content in the rat brain after continuous intracerebroventricular infusion of beta-amyloid(1-40) protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Orally active NGF synthesis stimulators: potential therapeutic agents in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Propentofylline improves learning and memory deficits in rats induced by beta-amyloid protein-(1-40).

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Perspectives of pharmacotherapy in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Improvement by nefiracetam of beta-amyloid-(1-42)-induced learning and memory impairments in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Long-term deprivation of oestrogens by ovariectomy potentiates beta-amyloid-induced working memory deficits in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nucleus basalis magnocellularis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2800%2900081-4

7 January 2021

10.1016/S0163-7258(00)00081-4

Identifiers

DOI

1 reference

31 July 2017

1 reference

PubMed ID

11150591