Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates (Q34123380)

31 July 2017

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates (English)

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31 July 2017

Manfred Jung

4

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Wolfgang Sippl

object named as

Wolfgang Sippl

series ordinal

3

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author name string

Silviya D Furdas

series ordinal

1

1 reference

PubMed ID

22234972

31 July 2017

Srinivasaraghavan Kannan

series ordinal

2

1 reference

31 July 2017

28 October 2011

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Archiv der Pharmazie - Chemistry in Life Sciences

31 July 2017

1 reference

31 July 2017

345

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31 July 2017

1

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31 July 2017

7-21

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Epigenetics: a historical overview

31 July 2017

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Epigenetics in human disease and prospects for epigenetic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Epigenetics--an epicenter of gene regulation: histones and histone-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Epigenetics and microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Protein modules that manipulate histone tails for chromatin regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Translating the Histone Code

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Crystal structure of the nucleosome core particle at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Chromatin modifications and their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

The language of covalent histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

The complex language of chromatin regulation during transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Chemical mechanisms of histone lysine and arginine modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Targeting the epigenome in the treatment of asthma and chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Phenotypic plasticity and the epigenetics of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

HAT-HDAC interplay modulates global histone H3K14 acetylation in gene-coding regions during stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Tuning acetylation levels with HAT activators: therapeutic strategy in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Chromatin remodeling in embryonic stem cells: regulating the balance between pluripotency and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Epigenetics in cancer: targeting chromatin modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

21 January 2018

Epigenetics in cancer

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Acetylation goes global: the emergence of acetylation biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Cohesin acetylation speeds the replication fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

New nomenclature for chromatin-modifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

MYST family histone acetyltransferases take center stage in stem cells and development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Steroid receptor coactivator-1 is a histone acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Acetylation of histones and transcription-related factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Autoacetylation regulates P/CAF nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Catalysis and substrate selection by histone/protein lysine acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Histone modifying enzymes: structures, mechanisms, and specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Histone acetyl transferases as emerging drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

A novel fusion variant of the MORF and CBP genes detected in therapy-related myelodysplastic syndrome with t(10;16)(q22;p13).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

RT-PCR and FISH analysis of acute myeloid leukemia with t(8;16)(p11;p13) and chimeric MOZ and CBP transcripts: breakpoint cluster region and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Specific inhibition of p300-HAT alters global gene expression and represses HIV replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Mice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Chemical biology of histone acetyltransferase natural compounds modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Inhibition of histone acetyltransferase by glycosaminoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Induction of autophagy by spermidine promotes longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Selective HAT inhibitors as mechanistic tools for protein acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Small molecule modulators of histone acetyltransferase p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Development of curcumin as an epigenetic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Histone acetyltransferase inhibitors and preclinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Mechanism of p300 specific histone acetyltransferase inhibition by small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Inhibition of lysine acetyltransferase KAT3B/p300 activity by a naturally occurring hydroxynaphthoquinone, plumbagin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Characterization of novel inhibitors of histone acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Nitric oxide-mediated histone hyperacetylation in oral cancer: target for a water-soluble HAT inhibitor, CTK7A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Design, synthesis, and biological evaluation of a small-molecule inhibitor of the histone acetyltransferase Gcn5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Isothiazolones as inhibitors of PCAF and p300 histone acetyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

ICM?A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

The identification of a novel natural activator of p300 histone acetyltranferase provides new insights into the modulation mechanism of this enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

Cinnamoyl Compounds as Simple Molecules that Inhibit p300 Histone Acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FARDP.201100209

21 January 2018

Identifiers

DOI

10.1002/ARDP.201100209

1 reference

31 July 2017

1 reference

PubMed ID

22234972