Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials (Q34014237)

30 July 2017

5 references

25 April 2019

25 June 2019

20 November 2019

15 December 2019

13 November 2020

Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials (English)

1 reference

30 July 2017

5 references

25 April 2019

25 June 2019

20 November 2019

15 December 2019

13 November 2020

1 reference

20 November 2019

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15 December 2019

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ChEBI release 2020-05-28

1 reference

13 November 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

author name string

Qiutian Jia

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

Hong Qing

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

language of work or name

English

0 references

publication date

17 July 2014

6 references

BioMed Research International

30 July 2017

25 April 2019

25 June 2019

20 November 2019

15 December 2019

13 November 2020

6 references

25 April 2019

25 June 2019

20 November 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

13 November 2020

2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

page(s)

837157

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

4 June 2020

copyright license

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25 April 2019

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on focus list of Wikimedia project

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copyright status

copyrighted

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ScienceSource

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The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice

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Testing the right target and right drug at the right stage

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The association of APOE genotype with cognitive function in persons aged 35 years or older

5 July 2018

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Systemic and central immunity in Alzheimer's disease: therapeutic implications

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A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect

5 July 2018

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5 July 2018

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Immunosenescence: what does it mean to health outcomes in older adults?

5 July 2018

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Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease

5 July 2018

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Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease

5 July 2018

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Secretase inhibitors and modulators for Alzheimer's disease treatment

5 July 2018

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A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

5 July 2018

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

5 July 2018

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Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

5 July 2018

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gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

5 July 2018

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The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

5 July 2018

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Development of AFFITOPE vaccines for Alzheimer's disease (AD)--from concept to clinical testing

5 July 2018

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Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

5 July 2018

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The quest for small molecules as amyloid inhibiting therapies for Alzheimer's disease

5 July 2018

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Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine.

5 July 2018

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Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

5 July 2018

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Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG).

5 July 2018

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Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets

5 July 2018

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The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

5 July 2018

1 reference

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Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease

5 July 2018

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

5 July 2018

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Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

5 July 2018

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PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease

5 July 2018

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

5 July 2018

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Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease

5 July 2018

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Current and future therapy in Alzheimer's disease.

5 July 2018

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Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

5 July 2018

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Memapsin 2 (beta-secretase) inhibitors: drug development

5 July 2018

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Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

5 July 2018

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Therapeutic potential of gamma-secretase inhibitors and modulators

5 July 2018

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Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

5 July 2018

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Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention

5 July 2018

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Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals

5 July 2018

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Function of COX-2 and prostaglandins in neurological disease

5 July 2018

1 reference

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Systematic review of information and support interventions for caregivers of people with dementia

5 July 2018

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Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages

5 July 2018

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Multi-target therapeutics: when the whole is greater than the sum of the parts

5 July 2018

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International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors

5 July 2018

1 reference

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Microglial control of neuronal death and synaptic properties

5 July 2018

1 reference

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A century of Alzheimer's disease

5 July 2018

1 reference

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Control of peripheral nerve myelination by the beta-secretase BACE1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease

5 July 2018

1 reference

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Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

5 July 2018

1 reference

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Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

5 July 2018

1 reference

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Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date

5 July 2018

1 reference

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Current pharmacotherapy for Alzheimer's disease

5 July 2018

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Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

5 July 2018

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Pharmacological strategies for the prevention of Alzheimer's disease

5 July 2018

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Global prevalence of dementia: a Delphi consensus study

5 July 2018

1 reference

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Direct regulation of intestinal fate by Notch

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Multiple cognitive deficits during the transition to Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Therapeutic effects of PKC activators in Alzheimer's disease transgenic mice

5 July 2018

1 reference

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Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

The potential for BACE1 inhibitors in the treatment of Alzheimer's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

A "mitochondrial cascade hypothesis" for sporadic Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Drugs targeting Alzheimer's disease: some things old and some things new.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Notch1 functions as a tumor suppressor in mouse skin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Alzheimer's disease is a synaptic failure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Estrogen (E2) and glucocorticoid (Gc) effects on microglia and A beta clearance in vitro and in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Nerve growth factor signaling, neuroprotection, and neural repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Piecing together Alzheimer's.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Clinical features of Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

EUROCARE: a cross-national study of co-resident spouse carers for people with Alzheimer's disease: II--A qualitative analysis of the experience of caregiving.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

EUROCARE: a cross-national study of co-resident spouse carers for people with Alzheimer's disease: I--Factors associated with carer burden

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

The role of APOE epsilon4 in modulating effects of other risk factors for cognitive decline in elderly persons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

A non-invasive system for delivering neural growth factors across the blood-brain barrier: a review

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Economic considerations in Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Blood-brain barrier penetration and in vivo activity of an NGF conjugate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Development of effective therapy for Alzheimer's disease based on neurotrophic factors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: response to fimbria-fornix transection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Gene therapy in the CNS: intracerebral grafting of genetically modified cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Alzheimer's disease: the amyloid cascade hypothesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Amyloid beta-peptide is produced by cultured cells during normal metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Alzheimer's disease: A conceptual history

5 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Neuropsychological features of mild cognitive impairment and preclinical Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Metaanalysis of randomized trials of the efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

BACE1 gene deletion: impact on behavioral function in a model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

A phase 3 trial of semagacestat for treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Identification of gamma-secretase inhibitor potency determinants on presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

BMS-708,163 targets presenilin and lacks notch-sparing activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Cerebrospinal fluid beta-amyloid and dynabridging in Alzheimer's disease drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Why did tarenflurbil fail in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Emerging and potential therapies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Amyloid fibril formation can proceed from different conformations of a partially unfolded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

The H1c haplotype at the MAPT locus is associated with Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Effect of physostigmine on memory consolidation and retrieval processes in intact and nucleus basalis-lesioned rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Development of microglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Immune system associated antigens expressed by cells of the human central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Nous sommes tous des bacteries: implications for medicine, pharmacology and public health.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Metabolic links between diabetes and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Liver X receptor activation restores memory in aged AD mice without reducing amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Regression stage senile plaques in the natural course of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F837157

Can lithium or valproate untie tangles in Alzheimer's disease?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid.

29 October 2018

1 reference

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Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4124758

Notch and the immune system

29 October 2018

1 reference

12 December 2020

ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families

1 reference

12 December 2020

Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease

1 reference

12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

12 December 2020

Identifiers

DOI

10.1155/2014/837157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

release_q3b7jbwdijbc3hg5u2wxiqekku

4 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/q3b7jbwdijbc3hg5u2wxiqekku

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25136630%20AND%20SRC:MED&resulttype=core&format=json