Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets (Q34784378)

4 August 2017

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title

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets (English)

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4 August 2017

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William L Klein

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4 August 2017

1 November 2002

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Neurochemistry International

4 August 2017

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4 August 2017

41

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4 August 2017

345-352

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4 August 2017

5

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Amyloid beta-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins

4 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Methodological variables in the assessment of beta amyloid neurotoxicity

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Self-assembly of Abeta(1-42) into globular neurotoxins.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Alzheimer's disease and transgenic mice.

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Wnt signaling function in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Spatial learning deficit in mice expressing human 751-amino acid beta-amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Structural neurology: are seeds at the root of neuronal degeneration?

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Cytotoxic amyloid peptides inhibit cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction by enhancing MTT formazan exocytosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Purification and characterization of brain clusterin

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Protein synthesis at synaptic sites on dendrites

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

The nanometer-scale structure of amyloid-beta visualized by atomic force microscopy

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from beta-amyloid-induced cell death by inhibiting the formation of beta-amyloid-derived diffusible neurotoxic ligands.

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

The role of A beta 42 in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

Morphological changes in dendritic spines associated with long-term synaptic plasticity

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

A beta peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line

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https://api.crossref.org/works/10.1016%2FS0197-0186%2802%2900050-5

7 January 2021

10.1016/S0197-0186(02)00050-5

Identifiers

DOI

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4 August 2017

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PubMed ID

12176077