Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats (Q33835006)

24927544

29 July 2017

title

Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats (English)

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29 July 2017

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4

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8 June 2020

Andrew B. West

5

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8 June 2020

author name string

João P L Daher

1

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8 June 2020

Laura A Volpicelli-Daley

2

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8 June 2020

Jonathan P Blackburn

3

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8 June 2020

language of work or name

English

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publication date

9 June 2014

1 reference

24927544

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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8 June 2020

volume

111

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8 June 2020

issue

25

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8 June 2020

page(s)

9289-9294

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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

8 June 2020

cites work

1 reference

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MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration

4 July 2018

1 reference

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Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

4 July 2018

1 reference

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

4 July 2018

1 reference

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

4 July 2018

1 reference

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High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078806

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

4 July 2018

1 reference

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LRRK2 inhibition attenuates microglial inflammatory responses

4 July 2018

1 reference

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Regulation of LRRK2 expression points to a functional role in human monocyte maturation

4 July 2018

1 reference

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A two-stage meta-analysis identifies several new loci for Parkinson's disease

4 July 2018

1 reference

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

4 July 2018

1 reference

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Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078806

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078806

The myeloid cells of the central nervous system parenchyma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078806

Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease.

4 July 2018

1 reference

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Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

4 July 2018

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Genomewide association study of leprosy

4 July 2018

1 reference

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LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control genetic study

4 July 2018

1 reference

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Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions

4 July 2018

1 reference

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LRRK2 G2019S as a cause of Parkinson's disease in Ashkenazi Jews.

4 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1403215111

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.

21 January 2018

1 reference

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Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078806

A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24927544

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1403215111

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8 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24927544%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

24927544

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24927544%20AND%20SRC:MED&resulttype=core&format=json