Regulation of LRRK2 expression points to a functional role in human monocyte maturation (Q28743193)

1

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Rosanna Pescini Gobert

2

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Robertus Hooft van Huijsduijnen

3

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Christoph Wiessner

4

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Yves Jean Sagot

Creative Commons Attribution 4.0 International

5

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language of work or name

English

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publication date

2011

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published in

PLOS One

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volume

6

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page(s)

e21519

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issue

6

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copyright license

start time

27 June 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

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Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

7 April 2017

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

3 June 2018

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LRRK2 is involved in the IFN-gamma response and host response to pathogens

3 June 2018

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

3 June 2018

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The WD40 domain is required for LRRK2 neurotoxicity

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3 June 2018

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Comparison of gene expression profiles between human and mouse monocyte subsets

3 June 2018

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Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

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3 June 2018

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Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

3 June 2018

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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

3 June 2018

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CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

3 June 2018

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Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.

3 June 2018

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LRRK2 in Parkinson's disease - drawing the curtain of penetrance: a commentary

3 June 2018

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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

3 June 2018

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Sequence conservation between porcine and human LRRK2.

3 June 2018

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3 June 2018

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Migratory fate and differentiation of blood monocyte subsets

3 June 2018

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3 June 2018

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The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting

3 June 2018

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3 June 2018

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LRRK2 is expressed in B-2 but not in B-1 B cells, and downregulated by cellular activation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation

27 November 2018

1 reference

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Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

Is there an association between the level of high-sensitivity C-reactive protein and idiopathic Parkinson's disease? A comparison of Parkinson's disease patients, disease controls and healthy individuals.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

Induction of CD83+CD14+ nondendritic antigen-presenting cells by exposure of monocytes to IFN-alpha

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

CD16+ human monocyte-derived dendritic cells matured with different and unrelated stimuli promote similar allogeneic Th2 responses: regulation by pro- and anti-inflammatory cytokines

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

CD14lowCD16high: a cytokine-producing monocyte subset which expands during human immunodeficiency virus infection

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124520

Surface Phenotype Analysis of Human Monocyte to Macrophage Maturation

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21738687

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Growth rate of patient-derived lymphoblastoid cells with LRRK2 mutations.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21738687

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21738687

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0021519

1 reference

1727945

ADS bibcode

2011PLoSO...621519T

0 references

1727945

1 reference

1 reference

1 reference