Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL (Q33819193)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813943%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813943%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

1 reference

Dominic P Del Re

1

1 reference

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18 March 2020

Takahisa Matsuda

2

1 reference

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18 March 2020

Peiyong Zhai

3

1 reference

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18 March 2020

Yasuhiro Maejima

4

1 reference

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18 March 2020

Mohit Raja Jain

5

1 reference

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18 March 2020

Hong Li

7

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18 March 2020

Chiao-Po Hsu

8

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18 March 2020

publication date

8 May 2014

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18 March 2020

1 reference

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18 March 2020

volume

54

1 reference

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18 March 2020

issue

4

1 reference

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18 March 2020

page(s)

639-650

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813943%20AND%20SRC:MED&resulttype=core&format=json

Many players in BCL-2 family affairs

18 March 2020

cites work

1 reference

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4 July 2018

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4 July 2018

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

4 July 2018

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Bax regulates primary necrosis through mitochondrial dynamics

4 July 2018

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4 July 2018

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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

4 July 2018

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The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes

4 July 2018

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4 July 2018

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4 July 2018

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Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice

4 July 2018

1 reference

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Still embedded together binding to membranes regulates Bcl-2 protein interactions.

4 July 2018

1 reference

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Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif

4 July 2018

1 reference

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Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes.

4 July 2018

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4 July 2018

The BCL-2 family reunion

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Rassf family of tumor suppressor polypeptides.

4 July 2018

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BAX activation is initiated at a novel interaction site

4 July 2018

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Lats2 is a negative regulator of myocyte size in the heart

4 July 2018

1 reference

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Ras oncogenes: split personalities

4 July 2018

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

4 July 2018

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

4 July 2018

1 reference

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The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis

4 July 2018

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Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy

4 July 2018

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Ras proteins: different signals from different locations

4 July 2018

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Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

4 July 2018

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Targeting RAS signalling pathways in cancer therapy

4 July 2018

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

4 July 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

4 July 2018

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Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

4 July 2018

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Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis

4 July 2018

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NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis

4 July 2018

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Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

4 July 2018

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K-ras is an essential gene in the mouse with partial functional overlap with N-ras

4 July 2018

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Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

4 July 2018

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

4 July 2018

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Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype

4 July 2018

1 reference

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

4 July 2018

1 reference

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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

4 July 2018

1 reference

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

4 July 2018

1 reference

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BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

4 July 2018

1 reference

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

4 July 2018

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p21ras as a common signaling target of reactive free radicals and cellular redox stress

4 July 2018

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

4 July 2018

1 reference

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Free radicals and myocardial ischemia and reperfusion injury

4 July 2018

1 reference

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BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

4 July 2018

1 reference

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In vivo gene delivery of HSP70i by adenovirus and adeno-associated virus preserves contractile function in mouse heart following ischemia-reperfusion

29 October 2018

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MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo.

29 October 2018

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Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis

29 October 2018

1 reference

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Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24813943

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24813943

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2014.04.007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813943%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813943%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24813943%20AND%20SRC:MED&resulttype=core&format=json