Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. (Q33818028)

29 July 2017

title

Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. (English)

1 reference

29 July 2017

author

Michel C. Nussenzweig

series ordinal

2

object named as

Michel C Nussenzweig

1 reference

Bernardo Reina San-Martin

29 July 2017

series ordinal

1

object named as

Bernardo Reina-San-Martin

1 reference

29 July 2017

André Nussenzweig

3

1 reference

29 July 2017

Simone Difilippantonio

series ordinal

4

1 reference

29 July 2017

publication date

24 January 2005

1 reference

Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

language of work or name

English

0 references

published in

1 reference

29 July 2017

volume

102

1 reference

29 July 2017

issue

5

1 reference

29 July 2017

page(s)

1590-1595

1 reference

ATM is required for efficient recombination between immunoglobulin switch regions

29 July 2017

cites work

1 reference

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Immunoglobulin class switch recombination is impaired in Atm-deficient mice

4 July 2018

1 reference

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Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

4 July 2018

1 reference

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Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch

4 July 2018

1 reference

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

4 July 2018

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Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

4 July 2018

1 reference

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Class-switch recombination: interplay of transcription, DNA deamination and DNA repair

4 July 2018

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Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

4 July 2018

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AID: how does it aid antibody diversity?

4 July 2018

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SV40 T antigen interacts with Nbs1 to disrupt DNA replication control.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

53BP1 is required for class switch recombination

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

The generation of antibody diversity through somatic hypermutation and class switch recombination

4 July 2018

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Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

4 July 2018

1 reference

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Requirement of the MRN complex for ATM activation by DNA damage

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Immunity through DNA deamination

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

A murine model of Nijmegen breakage syndrome

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Genomic instability in mice lacking histone H2AX

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Promotion of Dnl4-Catalyzed DNA End-Joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 Complexes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Chk2 activation dependence on Nbs1 after DNA damage

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

A mechanistic basis for Mre11-directed DNA joining at microhomologies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Immortalization and characterization of Nijmegen Breakage syndrome fibroblasts

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Ku80 is required for immunoglobulin isotype switching

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

4 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406289102

Nijmegen breakage syndrome. The International Nijmegen Breakage Syndrome Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406289102

Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406289102

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406289102

AID is required for c-myc/IgH chromosome translocations in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0406289102

Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=547831

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15668392

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The many interfaces of Mre11

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15668392

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0406289102

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference