Class-switch recombination: interplay of transcription, DNA deamination and DNA repair (Q28269740)

Nature Reviews Immunology

Europe PubMed Central

title

Class-switch recombination: interplay of transcription, DNA deamination and DNA repair (English)

0 references

author name string

Jayanta Chaudhuri

series ordinal

1

0 references

Frederick W Alt

series ordinal

2

0 references

language of work or name

English

0 references

publication date

July 2004

0 references

published in

0 references

volume

4

0 references

page(s)

541-52

0 references

issue

7

0 references

cites work

The mechanism and regulation of chromosomal V(D)J recombination

1 reference

Unraveling V(D)J recombination; insights into gene regulation

31 March 2020

1 reference

Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity

31 March 2020

1 reference

AID and mismatch repair in antibody diversification

31 March 2020

1 reference

Mechanism and control of class-switch recombination

31 March 2020

1 reference

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

31 March 2020

1 reference

Progress in understanding the mechanism and consequences of somatic hypermutation

31 March 2020

1 reference

Ig heavy chain class switching in Rag-deficient mice

31 March 2020

1 reference

DNA sequences at immunoglobulin switch region recombination sites

31 March 2020

1 reference

The influence of transcriptional orientation on endogenous switch region function

31 March 2020

1 reference

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

31 March 2020

1 reference

Immunity through DNA deamination

31 March 2020

1 reference

Immunoglobulin class switching

31 March 2020

1 reference

The mu switch region tandem repeats are important, but not required, for antibody class switch recombination

31 March 2020

1 reference

Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching.

31 March 2020

1 reference

Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region

31 March 2020

1 reference

Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences

31 March 2020

1 reference

Transcription-induced cleavage of immunoglobulin switch regions by nucleotide excision repair nucleases in vitro

31 March 2020

1 reference

RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination

31 March 2020

1 reference

Molecular visualization of immunoglobulin switch region RNA/DNA complex by atomic force microscope

31 March 2020

1 reference

R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells

31 March 2020

1 reference

Palindromic but not G-rich sequences are targets of class switch recombination

31 March 2020

1 reference

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

31 March 2020

1 reference

G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D, A role for G-G pairing in immunoglobulin switch recombination

31 March 2020

1 reference

Sequence specific thermodynamic and structural properties for DNA.RNA duplexes

31 March 2020

1 reference

Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions

31 March 2020

1 reference

Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals

31 March 2020

1 reference

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

31 March 2020

1 reference

Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations

31 March 2020

1 reference

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

31 March 2020

1 reference

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

31 March 2020

1 reference

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

31 March 2020

1 reference

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

31 March 2020

1 reference

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

31 March 2020

1 reference

Somatic hypermutation of the AID transgene in B and non-B cells

31 March 2020

1 reference

The AID enzyme induces class switch recombination in fibroblasts

31 March 2020

1 reference

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

31 March 2020

1 reference

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

31 March 2020

1 reference

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

31 March 2020

1 reference

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

31 March 2020

1 reference

AID mediates hypermutation by deaminating single stranded DNA.

31 March 2020

1 reference

Transcription-coupled events associating with immunoglobulin switch region chromatin

31 March 2020

1 reference

The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

31 March 2020

1 reference

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

31 March 2020

1 reference

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

31 March 2020

1 reference

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

31 March 2020

1 reference

53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

31 March 2020

1 reference

Ku80 is required for immunoglobulin isotype switching

31 March 2020

1 reference

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

31 March 2020

1 reference

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

31 March 2020

1 reference

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

31 March 2020

1 reference

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

31 March 2020

1 reference

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

31 March 2020

1 reference

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

31 March 2020

1 reference

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

31 March 2020

1 reference

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

31 March 2020

1 reference

Severe attenuation of the B cell immune response in Msh2-deficient mice

31 March 2020

1 reference

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

31 March 2020

1 reference

Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes

31 March 2020

1 reference

Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism

31 March 2020

1 reference

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination

31 March 2020

1 reference

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

31 March 2020

1 reference

Role for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctions

31 March 2020

1 reference

The Sμ Tandem Repeat Region Is Critical for Ig Isotype Switching in the Absence of Msh2

31 March 2020

1 reference

Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation

31 March 2020

1 reference

Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF

31 March 2020

1 reference

B cell differentiation and isotype switching is related to division cycle number

31 March 2020

1 reference

Single-strand interruptions in replicating chromosomes cause double-strand breaks

31 March 2020

1 reference

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

31 March 2020

1 reference

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line

31 March 2020

1 reference

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

31 March 2020

1 reference

Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination

31 March 2020

1 reference

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation

31 March 2020

1 reference

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

31 March 2020

1 reference

Alternative end joining during switch recombination in patients with ataxia-telangiectasia

31 March 2020

1 reference

ATM is not required in somatic hypermutation of VH, but is involved in the introduction of mutations in the switch mu region

31 March 2020

1 reference

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

31 March 2020

1 reference

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

31 March 2020

1 reference

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

31 March 2020

1 reference

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

31 March 2020

1 reference

Synapsis of DNA ends by DNA-dependent protein kinase

31 March 2020

1 reference

Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.

31 March 2020

1 reference

High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer

31 March 2020

1 reference

Mlh1 Can Function in Antibody Class Switch Recombination Independently of Msh2

31 March 2020

1 reference

The mismatch repair system is required for S-phase checkpoint activation

31 March 2020

1 reference

DNA-dependent protein kinase activity is not required for immunoglobulin class switching

31 March 2020

1 reference

Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions

31 March 2020

1 reference

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

31 March 2020

1 reference

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

31 March 2020

1 reference

AID mutant analyses indicate requirement for class-switch-specific cofactors

31 March 2020

1 reference

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

31 March 2020

1 reference

Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity

31 March 2020

1 reference

Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination

31 March 2020

1 reference

Evidence for class-specific factors in immunoglobulin isotype switching

31 March 2020

1 reference

Two new isotype-specific switching activities detected for Ig class switching

31 March 2020

1 reference

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

31 March 2020

1 reference

Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination

31 March 2020

1 reference