Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer (Q33740876)

29 July 2017

Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer (English)

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29 July 2017

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K S Kelly-Spratt

1

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29 July 2017

J Philipp-Staheli

2

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29 July 2017

K E Gurley

3

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29 July 2017

K Hoon-Kim

4

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29 July 2017

S Knoblaugh

5

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29 July 2017

C J Kemp

6

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29 July 2017

language of work or name

English

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publication date

3 August 2009

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29 July 2017

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29 July 2017

28

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29 July 2017

3652-3662

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29 July 2017

41

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https://scigraph.springernature.com/pub.10.1038/onc.2009.226

29 July 2017

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Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

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Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

21 June 2018

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 June 2018

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Restoration of p53 function leads to tumour regression in vivo

21 June 2018

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Modeling the therapeutic efficacy of p53 restoration in tumors

21 June 2018

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C-terminal phosphorylation controls the stability and function of p27kip1

21 June 2018

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A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

21 June 2018

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Prognostic implications of cell cycle, apoptosis, and angiogenesis biomarkers in non-small cell lung cancer: a review

21 June 2018

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Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization

21 June 2018

1 reference

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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

21 June 2018

1 reference

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Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate

21 June 2018

1 reference

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Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?

21 June 2018

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Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

p27Kip1 modulates cell migration through the regulation of RhoA activation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

21 June 2018

1 reference

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Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

21 June 2018

1 reference

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Primary lung tumors in mice as an aid for understanding, preventing, and treating human adenocarcinoma of the lung

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

21 June 2018

1 reference

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 June 2018

1 reference

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Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Cyclin E-CDK2 is a regulator of p27Kip1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Multiple mechanisms for p27(Kip1) translocation and degradation.

21 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.226

p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

P27 expression is regulated by separate signaling pathways, downstream of Ras, in each cell cycle phase

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Reduced expression of the cell cycle inhibitor p27Kip1 in non-small cell lung carcinoma: a prognostic factor independent of Ras

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2842079

Breast cancer banishes p27 from nucleus

30 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.226

High expression of Cks1 in human non-small cell lung carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.226

Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.226

Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.226

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19648963

12 December 2020

inferred from PubMed ID database lookup

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19648963

12 December 2020

inferred from PubMed ID database lookup

The absence of p27Kip1, an inhibitor of G1 cyclin-dependent kinases, uncouples differentiation and growth arrest during the granulosa->luteal transition

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19648963

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/ONC.2009.226

1 reference

Dimensions Publication ID

29 July 2017

1018391261

0 references

Fatcat ID

release_nzgdovb7dvextn5dykl46vj5yq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nzgdovb7dvextn5dykl46vj5yq

24 November 2022

mapped directly with Wikidata item

PMCID

2842079

1 reference

29 July 2017

1 reference