Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation (Q45140457)

10 December 2017

Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation (English)

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10 December 2017

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Yojiro Kotake

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10 December 2017

Keiko Nakayama

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2

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10 December 2017

Noriko Ishida

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3

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10 December 2017

Keiichi I Nakayama

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4

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10 December 2017

language of work or name

English

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publication date

3 November 2004

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Journal of Biological Chemistry

10 December 2017

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10 December 2017

280

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10 December 2017

2

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10 December 2017

1095-1102

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Principles of CDK regulation

10 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M406117200

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M406117200

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Translational control of p27Kip1 accumulation during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Cyclin E-CDK2 is a regulator of p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Degradation of p27(Kip1) at the G(0)-G(1) transition mediated by a Skp2-independent ubiquitination pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M406117200

21 January 2018

Identifiers

DOI

10.1074/JBC.M406117200

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10 December 2017

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