Expanding mTOR signaling (Q36902840)

17 August 2017

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title

Expanding mTOR signaling (English)

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17 August 2017

Qian Yang

1

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PubMed ID

17680028

17 August 2017

Kun-Liang Guan

series ordinal

2

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17 August 2017

1 August 2007

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17 August 2017

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17 August 2017

17

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17 August 2017

666-681

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17 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/cr.2007.64

17 August 2017

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cites work

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Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery

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Sirolimus for the Prevention of In-Stent Restenosis in a Coronary Artery

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7 January 2021

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

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7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

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7 January 2021

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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7 January 2021

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TOR signaling in growth and metabolism

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Targeting mTOR signaling for cancer therapy

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identification and characterization of a mitogen-activated S6 kinase

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The S6 kinase signaling pathway in the control of development and growth.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Regulation of translation initiation by FRAP/mTOR

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Tuberous sclerosis: from tubers to mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

United at last: the tuberous sclerosis complex gene products connect the phosphoinositide 3-kinase/Akt pathway to mammalian target of rapamycin (mTOR) signalling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The Akt-mTOR tango and its relevance to cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Cellular signaling: pivoting around PDK-1.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Intracellular signalling: PDK1--a kinase at the hub of things

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rheb binds and regulates the mTOR kinase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rheb fills a GAP between TSC and TOR.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

IRS proteins and the common path to diabetes

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The LKB1 tumor suppressor negatively regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Upstream and downstream of mTOR

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Molecular organization of target of rapamycin complex 2.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Growing roles for the mTOR pathway

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Regulation of Akt/PKB Ser473 phosphorylation

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Sin1: an evolutionarily conserved component of the eukaryotic SAPK pathway.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Unravelling the activation mechanisms of protein kinase B/Akt

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Mechanism of activation of protein kinase B by insulin and IGF-1

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Recent advances in the protein kinase B signaling pathway

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Structural and functional analysis of pp70S6k

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Signaling by target of rapamycin proteins in cell growth control

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

PTEN and myotubularin: novel phosphoinositide phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Drosophila Melted modulates FOXO and TOR activity.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Leptin and the regulation of body weight in mammals

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Central nervous system control of food intake

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https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Hypothalamic mTOR signaling regulates food intake

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.64

7 January 2021

Identifiers

DOI

10.1038/CR.2007.64

1 reference

PubMed ID

17680028

Dimensions Publication ID

17 August 2017

0 references

1 reference

PubMed ID

17680028