Genes and susceptible loci of Alzheimer's disease (Q33609365)

28 July 2017

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title

Genes and susceptible loci of Alzheimer's disease (English)

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28 July 2017

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Shastry BS

1

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PubMed ID

10230703

28 July 2017

Giblin FJ

series ordinal

2

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28 July 2017

1 January 1999

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28 July 2017

Brain Research Bulletin

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28 July 2017

48

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28 July 2017

2

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28 July 2017

121-127

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Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

28 July 2017

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The genetics of Alzheimer disease: current status and future prospects

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The presenilin genes: a new gene family involved in Alzheimer disease pathology

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Molecular genetic analysis of familial early-onset Alzheimer's disease linked to chromosome 14q24.3.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Chaperone-supervised conversion of prion protein to its protease-resistant form

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

First Alzheimer's diagnosis confirmed.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Presenilins: genes for life and death

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The Alzheimer family of diseases: many etiologies, one pathogenesis?

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

α-synuclein—a link between Parkinson and Alzheimer diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Mitochondrial DNA mutations in Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The presenilins and Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Presenilins and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Association at LRP gene locus with sporadic late-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

1 reference

7 January 2021

Advances fuel Alzheimer's conundrum.

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Alzheimer's disease-associated presenilins 1 and 2: accelerated amyloid fibril formation of mutant 410 Cys-->Tyr and 141 Asn-->Ile peptides.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Genetic testing for Alzheimer disease. Practical and ethical issues

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Alzheimer diseases: a model of gene mutations and susceptibility polymorphisms for complex psychiatric diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Genetic dissection of Alzheimer disease, a heterogeneous disorder

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https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Molecular genetics of familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Pathological changes in olfactory neurons in patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Presenilins and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

Mechanisms of neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

A genome survey for novel Alzheimer disease risk loci: results at 10-cM resolution.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2898%2900156-7

7 January 2021

10.1016/S0361-9230(98)00156-7

Identifiers

DOI

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28 July 2017

1 reference

PubMed ID

10230703