Genetic dissection of Alzheimer disease, a heterogeneous disorder (Q33909158)

29 July 2017

title

Genetic dissection of Alzheimer disease, a heterogeneous disorder (English)

1 reference

29 July 2017

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G D Schellenberg

1

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29 July 2017

publication date

1 September 1995

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29 July 2017

language of work or name

English

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number of pages

8

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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29 July 2017

volume

92

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29 July 2017

issue

19

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29 July 2017

page(s)

8552-8559

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publication type of scholarly work

29 July 2017

review article

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FAMILIAL ALZHEIMER'S DISEASE

cites work

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Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

5 July 2018

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Isoform-specific binding of apolipoprotein E to beta-amyloid

5 July 2018

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Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

5 July 2018

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5 July 2018

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Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

5 July 2018

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APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease

5 July 2018

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Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII genes due to linkage disequilibrium?

5 July 2018

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Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease

5 July 2018

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Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex

5 July 2018

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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

5 July 2018

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

5 July 2018

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A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21.

5 July 2018

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

5 July 2018

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Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

5 July 2018

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Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2)

5 July 2018

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APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain.

5 July 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

5 July 2018

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Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

5 July 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

5 July 2018

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Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease

5 July 2018

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Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

5 July 2018

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Familial Alzheimer's disease in American descendants of the Volga Germans: probable genetic founder effect

5 July 2018

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Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families.

5 July 2018

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

5 July 2018

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Genetic linkage studies in Alzheimer's disease families

5 July 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

5 July 2018

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

5 July 2018

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Down's syndrome and Alzheimer's disease: a review

5 July 2018

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Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

5 July 2018

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Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

5 July 2018

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

5 July 2018

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The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene

5 July 2018

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Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

5 July 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

5 July 2018

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The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

5 July 2018

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Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported

5 July 2018

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The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons

5 July 2018

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

5 July 2018

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A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein

5 July 2018

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Predisposing locus for Alzheimer's disease on chromosome 21.

5 July 2018

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A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

5 July 2018

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Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I

5 July 2018

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

5 July 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

5 July 2018

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Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage

5 July 2018

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Familial Alzheimer disease: a large, multigeneration German kindred

5 July 2018

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Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease

5 July 2018

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Linkage analysis of familial Alzheimer disease, using chromosome 21 markers

5 July 2018

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Early-onset Alzheimer's disease in 2 large Belgian families

5 July 2018

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Hippocampal lesions in dominantly inherited Alzheimer's disease

5 July 2018

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

5 July 2018

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Molecular genetics of Alzheimer disease amyloid

5 July 2018

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A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

5 July 2018

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The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

5 July 2018

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Anti‐inflammatory agents as a therapeutic approach to Alzheimer's disease

5 July 2018

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Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

5 July 2018

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A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs

5 July 2018

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Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing

5 July 2018

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APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease

5 July 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases

5 July 2018

1 reference

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

5 July 2018

1 reference

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Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

5 July 2018

1 reference

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Amyloid beta-peptide is produced by cultured cells during normal metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.

5 July 2018

1 reference

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

5 July 2018

1 reference

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Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

APP717 and Alzheimer's disease in Italy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

No linkage to chromosome 14 in Swedish Alzheimer's disease families

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Confirmation of the epsilon 4 allele of the apolipoprotein E gene as a risk factor for late-onset Alzheimer's disease.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Age of onset in familial early onset Alzheimer's disease correlates with genetic aetiology.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Alzheimer's disease and possible gene interaction

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Beta A4-amyloid protein precursor mRNA isoforms without exon 15 are ubiquitously expressed in rat tissues including brain, but not in neurons.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

The c-fos gene and early-onset familial Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Analysis of the c-FOS gene on chromosome 14 and the promoter of the amyloid precursor protein gene in familial Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Alzheimer's disease, apolipoprotein E4, and gender

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E genotype and Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E polymorphism and Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

The apolipoprotein E epsilon 4 allele does not influence the clinical expression of the amyloid precursor protein gene codon 693 or 692 mutations

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Chromosome 14-encoded Alzheimer's disease: genetic and clinicopathological description

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

A large Swedish family with Alzheimer's disease with a codon 670/671 amyloid precursor protein mutation. A clinical and genealogical investigation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E-epsilon 4 allele doses in late-onset Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Dose-dependent association of apolipoprotein E allele epsilon 4 with late-onset, sporadic Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E4 allele and Alzheimer disease: examination of allelic association and effect on age at onset in both early- and late-onset cases

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

A family with histologically confirmed Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=41005

Apolipoprotein E genotype and Alzheimer's disease

29 October 2018

1 reference

12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

12 December 2020

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

1 reference

12 December 2020

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

1 reference

12 December 2020

Assignment of a familial Alzheimer's disease locus between D14S289 and D14S53

1 reference

12 December 2020

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

12 December 2020

No protective effect of apolipoprotein E epsilon 2 allele in Dutch hereditary cerebral amyloid angiopathy

1 reference

12 December 2020

Familial Alzheimer's disease

1 reference

12 December 2020

Phenotypic heterogeneity in familial Alzheimer's disease: a study of 24 kindreds

1 reference

12 December 2020

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

1 reference

12 December 2020

Myoclonus, seizures, and paratonia in Alzheimer disease

1 reference

12 December 2020

Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease

1 reference

12 December 2020

Familial Alzheimer's disease in two kindreds of the same geographic and ethnic origin. A clinical and genetic study

1 reference

12 December 2020

Lipoprotein uptake by neuronal growth cones in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.92.19.8552

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference