Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons (Q33579072)

28 July 2017

title

Metabolic stress modulates Alzheimer's β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons (English)

1 reference

28 July 2017

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Robert W Williams

9

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author name string

Ruishan Wang

1

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28 July 2017

Jing Jing Li

2

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28 July 2017

Shiyong Diao

3

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28 July 2017

Young-Don Kwak

4

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28 July 2017

Li Liu

5

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28 July 2017

Lianteng Zhi

6

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28 July 2017

Hansruedi Büeler

7

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28 July 2017

Narayan R Bhat

8

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28 July 2017

Edwards A Park

10

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28 July 2017

Francesca-Fang Liao

11

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28 July 2017

publication date

1 May 2013

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28 July 2017

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28 July 2017

volume

17

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28 July 2017

issue

5

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28 July 2017

page(s)

685-694

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Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

28 July 2017

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21 June 2018

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21 June 2018

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PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

21 June 2018

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

21 June 2018

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Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

21 June 2018

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21 June 2018

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21 June 2018

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Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

21 June 2018

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 June 2018

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Nuclear receptor corepressors and PPARgamma

21 June 2018

1 reference

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The transcription factor Yin Yang 1 is an activator of BACE1 expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

21 June 2018

1 reference

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Metabolic control through the PGC-1 family of transcription coactivators

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes

21 June 2018

1 reference

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Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

21 June 2018

1 reference

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Biological control through regulated transcriptional coactivators

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

21 June 2018

1 reference

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 June 2018

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Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

21 June 2018

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

21 June 2018

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Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

21 June 2018

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21 June 2018

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21 June 2018

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Levels of beta-secretase BACE and alpha-secretase ADAM10 mRNAs in Alzheimer hippocampus

21 June 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 June 2018

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Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice.

21 June 2018

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AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

31 October 2018

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SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells

31 October 2018

1 reference

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High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.

31 October 2018

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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5396538

10.1016/J.CMET.2013.03.016

31 October 2018

Identifiers

DOI

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28 July 2017

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28 July 2017

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