Deconstructing repression: evolving models of co-repressor action (Q37677559)

21 August 2017

title

Deconstructing repression: evolving models of co-repressor action (English)

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21 August 2017

3

Christopher K Glass

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21 August 2017

Valentina Perissi

1

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21 August 2017

Kristen Jepsen

series ordinal

2

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21 August 2017

Michael G Rosenfeld

series ordinal

4

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21 August 2017

publication date

1 February 2010

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21 August 2017

language of work or name

English

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published in

Nature Reviews Genetics

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21 August 2017

volume

11

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21 August 2017

issue

2

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21 August 2017

page(s)

109-123

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publication type of scholarly work

21 August 2017

review article

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Chromatin remodeling: insights and intrigue from single-molecule studies

cites work

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Covalent modifications of histones during development and disease pathogenesis

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Chromatin modifications and their function

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Crosstalk among Histone Modifications

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The language of covalent histone modifications

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Transcription dynamics

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Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

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A transcriptional co-repressor that interacts with nuclear hormone receptors

31 March 2020

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A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression

31 March 2020

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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

31 March 2020

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Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

31 March 2020

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Context-dependent regulation of Groucho/TLE-mediated repression

31 March 2020

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Genome-wide patterns of histone modifications in yeast.

31 March 2020

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Polycomb response elements and targeting of Polycomb group proteins in Drosophila.

31 March 2020

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The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program

31 March 2020

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SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development.

31 March 2020

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Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

31 March 2020

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LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

31 March 2020

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Histone H2A ubiquitination in transcriptional regulation and DNA damage repair

31 March 2020

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Histone ubiquitination: triggering gene activity

31 March 2020

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Recent progress in the biology and physiology of sirtuins

31 March 2020

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Class IIa histone deacetylases: conducting development and differentiation

31 March 2020

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Class II histone deacetylases: versatile regulators

31 March 2020

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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

31 March 2020

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Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex

31 March 2020

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Histone deacetylase activity is required for full transcriptional repression by mSin3A

31 March 2020

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Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

31 March 2020

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CoREST is an integral component of the CoREST- human histone deacetylase complex

31 March 2020

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A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes

31 March 2020

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Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

31 March 2020

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Histone deacetylase directs the dominant silencing of transcription in chromatin: association with MeCP2 and the Mi-2 chromodomain SWI/SNF ATPase

31 March 2020

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NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities

31 March 2020

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The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities

31 March 2020

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Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3

31 March 2020

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Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1

31 March 2020

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Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

31 March 2020

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N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso

31 March 2020

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Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo

31 March 2020

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Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR

31 March 2020

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Coactivator and corepressor complexes in nuclear receptor function

31 March 2020

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Molecular determinants of nuclear receptor-corepressor interaction

31 March 2020

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The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

31 March 2020

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Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter

31 March 2020

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Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator

31 March 2020

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Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes

31 March 2020

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SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival

31 March 2020

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ChIP-seq: advantages and challenges of a maturing technology

31 March 2020

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Insights from genomic profiling of transcription factors

31 March 2020

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High-resolution profiling of histone methylations in the human genome

31 March 2020

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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

31 March 2020

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Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

31 March 2020

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ChIP-seq accurately predicts tissue-specific activity of enhancers

31 March 2020

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Control of developmental regulators by Polycomb in human embryonic stem cells

31 March 2020

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

31 March 2020

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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

31 March 2020

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Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes

31 March 2020

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Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.

31 March 2020

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The SMRT corepressor is regulated by a MEK-1 kinase pathway: inhibition of corepressor function is associated with SMRT phosphorylation and nuclear export

31 March 2020

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N-CoR controls differentiation of neural stem cells into astrocytes

31 March 2020

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A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors

31 March 2020

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Reading and function of a histone code involved in targeting corepressor complexes for repression

31 March 2020

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The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor

31 March 2020

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TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints

31 March 2020

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Activating the PARP-1 sensor component of the groucho/ TLE1 corepressor complex mediates a CaMKinase IIdelta-dependent neurogenic gene activation pathway

31 March 2020

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A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

31 March 2020

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma

31 March 2020

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Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

31 March 2020

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Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint

31 March 2020

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Negative regulation of hormone signaling by RIP140.

31 March 2020

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Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing

31 March 2020

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The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling

31 March 2020

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Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms

31 March 2020

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Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR.

31 March 2020

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An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens

31 March 2020

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Corepressor recruitment by agonist-bound nuclear receptors

31 March 2020

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Corepressors of agonist-bound nuclear receptors

31 March 2020

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Novel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants

31 March 2020

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TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77

31 March 2020

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Cooperative regulation in development by SMRT and FOXP1

31 March 2020

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Combinatorial roles of the nuclear receptor corepressor in transcription and development

31 March 2020

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SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

31 March 2020

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JmjC-domain-containing proteins and histone demethylation

31 March 2020

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UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

31 March 2020

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The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing

31 March 2020

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Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases

31 March 2020

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A histone H3 lysine 27 demethylase regulates animal posterior development

31 March 2020

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Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination

31 March 2020

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JMJD3 is a histone H3K27 demethylase.

31 March 2020

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

31 March 2020

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Regulation of stem cell differentiation by histone methyltransferases and demethylases

31 March 2020

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Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development

31 March 2020

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

31 March 2020

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Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells

31 March 2020

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The genomic landscape of histone modifications in human T cells

31 March 2020

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SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis

31 March 2020

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The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

31 March 2020

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Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks

31 March 2020

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Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

31 March 2020

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Function of retinoic acid receptors during embryonic development

31 March 2020

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The skeletal phenotypes of TRalpha and TRbeta mutant mice

31 March 2020

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Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control

31 March 2020

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Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

31 March 2020

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Active repression of RAR signaling is required for head formation

31 March 2020

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Corepressor requirement and thyroid hormone receptor function during Xenopus development

31 March 2020

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

31 March 2020

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Nuclear receptor coregulators and human disease

31 March 2020

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Defective Release of Corepressor by Hinge Mutants of the Thyroid Hormone Receptor Found in Patients with Resistance to Thyroid Hormone

31 March 2020

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Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors

31 March 2020

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HDAC3: taking the SMRT-N-CoRrect road to repression

31 March 2020

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Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

31 March 2020

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Identification of tumor precursor cells in the brains of primates with radiation-induced de novo glioblastoma multiforme

31 March 2020

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N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation

31 March 2020

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Identification of human brain tumour initiating cells

31 March 2020

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Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers

31 March 2020

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Aberrant cytoplasmic localization of N-CoR in colorectal tumors

31 March 2020

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Expression of steroid receptor coactivators and corepressors in human endometrial hyperplasia and carcinoma with relevance to steroid receptors and Ki‐67 expression

31 March 2020

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Nuclear neighborhoods and gene expression

31 March 2020

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The 4C technique: the 'Rosetta stone' for genome biology in 3D?

31 March 2020

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SMRT and N-CoR corepressors are regulated by distinct kinase signaling pathways

31 March 2020

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The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains

31 March 2020

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Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor

31 March 2020

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The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).

31 March 2020

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Stoichiometric and steric principles governing repression by nuclear hormone receptors

31 March 2020

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The SWI/SNF complex and cancer

31 March 2020

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The BRG1 transcriptional coregulator

31 March 2020

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Mechanisms of polycomb gene silencing: knowns and unknowns

31 March 2020

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Essential role of the glycosyltransferase sxc/Ogt in polycomb repression.

31 March 2020

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The human Mi-2/NuRD complex and gene regulation

31 March 2020

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CoREST-like complexes regulate chromatin modification and neuronal gene expression

31 March 2020

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The transcriptional corepressor CtBP: a foe of multiple tumor suppressors

31 March 2020

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The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

31 March 2020

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Sin3: master scaffold and transcriptional corepressor

31 March 2020

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A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1

31 March 2020

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The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

31 March 2020

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DNA methylation and methyl-CpG binding proteins: developmental requirements and function

31 March 2020

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Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

31 March 2020

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Sin3: a flexible regulator of global gene expression and genome stability.

31 March 2020

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Sirtuins: critical regulators at the crossroads between cancer and aging

31 March 2020

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Polybromo protein BAF180 functions in mammalian cardiac chamber maturation

31 March 2020

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ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a

31 March 2020

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Regulation of dendritic development by neuron-specific chromatin remodeling complexes

31 March 2020

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

31 March 2020

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A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

31 March 2020

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Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).

31 March 2020

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The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development

31 March 2020

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Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.

31 March 2020

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Positional cloning of a global regulator of anterior-posterior patterning in mice

31 March 2020

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The polycomb-group gene Ezh2 is required for early mouse development

31 March 2020

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Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

31 March 2020

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Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity

31 March 2020

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Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

31 March 2020

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Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development

31 March 2020

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Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

31 March 2020

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Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

31 March 2020

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Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10

31 March 2020

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Epigenetic control of skull morphogenesis by histone deacetylase 8

31 March 2020

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31 March 2020

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Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus-like autoimmune disease in mice

31 March 2020

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Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells

31 March 2020

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Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease

31 March 2020

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Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes

31 March 2020

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Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

31 March 2020

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mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival

31 March 2020

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Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation

31 March 2020

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

31 March 2020

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

31 March 2020

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

31 March 2020

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

31 March 2020

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

31 March 2020

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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

31 March 2020

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Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

31 March 2020

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TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling

31 March 2020

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Kaiso-deficient mice show resistance to intestinal cancer

31 March 2020

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Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects

31 March 2020

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12 December 2020

Loss- and gain-of-function mutations show a polycomb group function for Ring1A in mice

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12 December 2020

Signaling by Tyrosine Kinases Negatively Regulates the Interaction between Transcription Factors and SMRT (Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor) Corepressor

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12 December 2020

Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.

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12 December 2020

Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma.

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12 December 2020

A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness

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12 December 2020

Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway

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12 December 2020

The coregulator exchange in transcriptional functions of nuclear receptors

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12 December 2020

The eed mutation disrupts anterior mesoderm production in mice

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12 December 2020

Identifiers

DOI

10.1038/NRG2736

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Dimensions Publication ID

21 August 2017

1008020612

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