Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy (Q33515031)

27 July 2017

Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy (English)

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27 July 2017

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acute myeloid leukemia

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Thorsten Stiewe

7

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Martin Eilers

object named as

Martin Eilers

8

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author name string

Mona Meyer

1

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27 July 2017

Daniela Rübsamen

2

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27 July 2017

Robert Slany

3

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27 July 2017

Thomas Illmer

4

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27 July 2017

Kathleen Stabla

5

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27 July 2017

Petra Roth

6

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27 July 2017

Andreas Neubauer

9

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27 July 2017

language of work or name

English

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publication date

5 November 2009

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27 July 2017

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27 July 2017

4

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27 July 2017

11

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27 July 2017

e7768

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Creative Commons Attribution 4.0 International

27 July 2017

start time

5 November 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2.

21 June 2018

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The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts

21 June 2018

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Modeling the initiation and progression of human acute leukemia in mice

21 June 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 June 2018

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21 June 2018

Acute myeloid leukaemia

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Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

21 June 2018

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Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.

21 June 2018

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Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

21 June 2018

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Implications of NRAS mutations in AML: a study of 2502 patients

21 June 2018

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 June 2018

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Genetics of myeloid malignancies: pathogenetic and clinical implications

21 June 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 June 2018

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Tumour biology: senescence in premalignant tumours

21 June 2018

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MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

21 June 2018

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Drug therapy for acute myeloid leukemia

21 June 2018

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Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice

21 June 2018

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Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage

21 June 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 June 2018

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

21 June 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 June 2018

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21 June 2018

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Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization

21 June 2018

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Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

21 June 2018

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A stem cell molecular signature

21 June 2018

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Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors

21 June 2018

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 June 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 June 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 June 2018

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Curative chemotherapy for acute myeloid leukemia: the development of high-dose ara-C from the laboratory to bedside

21 June 2018

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Induction of monocytic differentiation and tumorigenicity by v-Ha-ras in differentiation arrested hematopoietic cells.

21 June 2018

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N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome

21 June 2018

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Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.

21 June 2018

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21 June 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

21 June 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 June 2018

1 reference

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Hematopoietic transforming potential of activated ras in chimeric mice.

21 June 2018

1 reference

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ras oncogenes in human cancer: a review

21 June 2018

1 reference

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Effect of cytosine arabinoside on differentiation of normal human bone marrow cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767509

The v-ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767509

Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo

21 June 2018

1 reference

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Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

N-ras oncogene-induced gene expression in human hematopoietic progenitor cells: upregulation of p16INK4a and p21CIP1/WAF1 correlates with myeloid differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

The power and the promise of oncogene-induced senescence markers.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

Ras induces chromosome instability and abrogation of the DNA damage response.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007768

MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2767509

Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases

31 October 2018

1 reference

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Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

31 October 2018

1 reference

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Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.

31 October 2018

1 reference

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Expression of normal and mutant ras proteins in human acute leukemia

31 October 2018

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12 December 2020

A study on the induction of differentiation of human leukemic cells by harringtonine combined with cytarabine

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12 December 2020

The incidence and prognostic significance of mutations in codon 13 of the N-ras gene in acute myeloid leukemia

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12 December 2020

Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice

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12 December 2020

10.1371/JOURNAL.PONE.0007768

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DOI

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27 July 2017

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27 July 2017

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