Methodological approaches in application of synthetic lethality screening towards anticancer therapy (Q33421697)

26 July 2017

2 references

19 September 2019

14 September 2020

Methodological approaches in application of synthetic lethality screening towards anticancer therapy (English)

1 reference

biomedical investigative technique

26 July 2017

1 reference

19 September 2019

1 reference

14 September 2020

D Canaani

1

1 reference

26 July 2017

language of work or name

English

0 references

publication date

24 March 2009

1 reference

British Journal of Cancer

26 July 2017

21 April 2009

2 references

19 September 2019

14 September 2020

3 references

26 July 2017

19 September 2019

14 September 2020

100

1 reference

26 July 2017

8

1 reference

26 July 2017

1213-1218

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.bjc.6605000

26 July 2017

0 references

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28 July 2018

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Targeted therapy for cancer using PARP inhibitors

28 July 2018

1 reference

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A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy

28 July 2018

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

28 July 2018

1 reference

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Utilizing RNA interference to enhance cancer drug discovery

28 July 2018

1 reference

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Synthetic lethal screen identification of chemosensitizer loci in cancer cells

28 July 2018

1 reference

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New approaches to molecular cancer therapeutics

28 July 2018

1 reference

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Mitochondriotoxic compounds for cancer therapy

28 July 2018

1 reference

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The new era in cancer research

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Validating cancer drug targets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Revealing complex traits with small molecules and naturally recombinant yeast strains

28 July 2018

1 reference

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A loss-of-function RNA interference screen for molecular targets in cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Global synthetic-lethality analysis and yeast functional profiling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

The concept of synthetic lethality in the context of anticancer therapy

28 July 2018

1 reference

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

shRNA-mediated RNA interference as a tool for genetic synthetic lethality screening in mouse embryo fibroblasts

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Can the pharmaceutical industry reduce attrition rates?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Replication and episomal maintenance of Epstein-Barr virus-based vectors in mouse embryonal fibroblasts enable synthetic lethality screens

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

28 July 2018

1 reference

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A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

28 July 2018

1 reference

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Genetic synthetic lethality screen at the single gene level in cultured human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Use of isogenic human cancer cells for high-throughput screening and drug discovery

28 July 2018

1 reference

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Establishment of a chemical synthetic lethality screen in cultured human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Integrating genetic approaches into the discovery of anticancer drugs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Establishing genetic interactions by a synthetic dosage lethality phenotype.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Tumour suppression by the human von Hippel-Lindau gene product

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Cell-based assays for identification of novel double-strand break-inducing agents

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605000

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605000

DNA repair pathways as targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605000

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

21 January 2018

1 reference

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A Robust Toolkit for Functional Profiling of the Yeast Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605000

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605000

Cancer proliferation gene discovery through functional genomics.

21 January 2018

1 reference

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Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605000

Chemical-genetic approaches for exploring the mode of action of natural products

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

Synthetic genetic array analysis in Saccharomyces cerevisiae.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676542

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19319136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19319136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6605000

1 reference

Dimensions Publication ID

26 July 2017

0 references

1 reference

26 July 2017

1 reference