An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF. (Q33396954)

26 July 2017

title

An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF. (English)

1 reference

26 July 2017

Hayate Merad

1

1 reference

26 July 2017

Horea Porumb

2

1 reference

26 July 2017

Loussiné Zargarian

3

1 reference

26 July 2017

Brigitte René

4

1 reference

26 July 2017

Zeina Hobaika

5

1 reference

26 July 2017

Richard G Maroun

6

1 reference

26 July 2017

Olivier Mauffret

7

1 reference

26 July 2017

Serge Fermandjian

8

1 reference

26 July 2017

language of work or name

English

0 references

publication date

1 January 2009

1 reference

26 July 2017

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26 July 2017

volume

4

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26 July 2017

issue

1

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26 July 2017

page(s)

e4081

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Creative Commons Attribution 4.0 International

26 July 2017

copyright license

start time

1 January 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Small-angle X-ray characterization of the nucleoprotein complexes resulting from DNA-induced oligomerization of HIV-1 integrase

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Identification of the LEDGF/p75 binding site in HIV-1 integrase

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An essential role for LEDGF/p75 in HIV integration

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

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14 July 2018

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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

14 July 2018

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Self-association and domains of interactions of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by analytical ultracentrifugation and NMR experiments in trifluoroethanol/H(2)O mixtures

14 July 2018

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Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

14 July 2018

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The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity

14 July 2018

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HIV-1 integrase: structural organization, conformational changes, and catalysis

14 July 2018

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Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction

14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Solution structure of the DNA binding domain of HIV-1 integrase

14 July 2018

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The DNA-binding domain of HIV-1 integrase has an SH3-like fold

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607020

DNA recognition by proteins with the helix-turn-helix motif

14 July 2018

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Application of fluorescence energy transfer and polarization to monitor Escherichia coli cAMP receptor protein and lac promoter interaction

14 July 2018

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Environment affects amino acid preference for secondary structure

14 July 2018

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Mutational analysis of the integrase protein of human immunodeficiency virus type 2

14 July 2018

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14 July 2018

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Transpositional recombination: mechanistic insights from studies of mu and other elements

14 July 2018

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Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration.

14 July 2018

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A three-dimensional model of the human immunodeficiency virus type 1 integration complex

21 January 2018

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Modeling HIV-1 integrase complexes based on their hydrodynamic properties

21 January 2018

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Identification of amino acids in HIV-1 and avian sarcoma virus integrase subsites required for specific recognition of the long terminal repeat Ends

21 January 2018

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Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex

21 January 2018

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Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 January 2018

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HIV-1 infection requires a functional integrase NLS.

21 January 2018

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A synthetic peptide bearing the HIV-1 integrase 161-173 amino acid residues mediates active nuclear import and binding to importin alpha: characterization of a functional nuclear localization signal

21 January 2018

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GOR method for predicting protein secondary structure from amino acid sequence.

21 January 2018

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Determinants of Mg2+-dependent activities of recombinant human immunodeficiency virus type 1 integrase

21 January 2018

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Fluorescence methods for studying equilibrium macromolecule-ligand interactions

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Fluorescence approaches to study of protein-nucleic acid complexation

21 January 2018

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Circular dichroism and fluorescence of a tyrosine side-chain residue monitors the concentration-dependent equilibrium between U-shaped and coiled-coil conformations of a peptide derived from the catalytic core of HIV-1 integrase

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2607020

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31 October 2018

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The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc

31 October 2018

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12 December 2020

Conformational aspects of HIV-1 integrase inhibition by a peptide derived from the enzyme central domain and by antibodies raised against this peptide

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Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.

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Self-association and DNA binding properties of the human topoisomerase IIA alpha2HTH module

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Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme

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Peptide inhibitors of HIV-1 integrase dissociate the enzyme oligomers

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Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence

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12 December 2020

10.1371/JOURNAL.PONE.0004081

Identifiers

DOI

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26 July 2017

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26 July 2017

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