Integrase inhibitors to treat HIV/AIDS. (Q34397376)

1 August 2017

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title

Integrase inhibitors to treat HIV/AIDS. (English)

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1 August 2017

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1

Yves Pommier

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1 August 2017

Allison A Johnson

2

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PubMed ID

15729361

1 August 2017

Christophe Marchand

series ordinal

3

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1 August 2017

1 March 2005

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Nature Reviews Drug Discovery

1 August 2017

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1 August 2017

4

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1 August 2017

3

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1 August 2017

236-248

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https://scigraph.springernature.com/pub.10.1038/nrd1660

1 August 2017

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cites work

Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency

1 reference

An outbreak of community-acquired Pneumocystis carinii pneumonia: initial manifestation of cellular immune dysfunction

31 March 2020

1 reference

Severe Acquired Immunodeficiency in Male Homosexuals, Manifested by Chronic Perianal Ulcerative Herpes Simplex Lesions

31 March 2020

1 reference

Public health. Whatever happened to the U.S. AIDS epidemic?

31 March 2020

1 reference

31 March 2020

1 reference

Therapies. Confronting the limits of success.

31 March 2020

1 reference

Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques

31 March 2020

1 reference

31 March 2020

1 reference

Inhibitors of human immunodeficiency virus integrase

31 March 2020

1 reference

Inhibition of HIV-1 integration protein by aurintricarboxylic acid monomers, monomer analogs, and polymer fractions

31 March 2020

1 reference

Inhibitory effect of the polyanionic drug suramin on the in vitro HIV DNA integration reaction

31 March 2020

1 reference

Identification of critical amino acid residues in human immunodeficiency virus type 1 IN required for efficient proviral DNA formation at steps prior to integration in dividing and nondividing cells.

31 March 2020

1 reference

Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.

31 March 2020

1 reference

Human cell proteins and human immunodeficiency virus DNA integration

31 March 2020

1 reference

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

31 March 2020

1 reference

The Human Polycomb Group EED Protein Interacts with the Integrase of Human Immunodeficiency Virus Type 1

31 March 2020

1 reference

Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60

31 March 2020

1 reference

Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication

31 March 2020

1 reference

HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro

31 March 2020

1 reference

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes

31 March 2020

1 reference

Reversal of Integration and DNA Splicing Mediated by Integrase of Human Immunodeficiency Virus

31 March 2020

1 reference

Repair of gaps in retroviral DNA integration intermediates

31 March 2020

1 reference

Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway

31 March 2020

1 reference

HIV-1 integration in the human genome favors active genes and local hotspots

31 March 2020

1 reference

Target-sequence preferences of HIV-1 integration complexes in vitro.

31 March 2020

1 reference

Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection

31 March 2020

1 reference

Transcription start regions in the human genome are favored targets for MLV integration

31 March 2020

1 reference

Structure and function of HIV-1 integrase

31 March 2020

1 reference

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

31 March 2020

1 reference

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

31 March 2020

1 reference

Recombining the structures of HIV integrase, RuvC and RNase H.

31 March 2020

1 reference

Crystal structure of Argonaute and its implications for RISC slicer activity

31 March 2020

1 reference

Comparative architecture of transposase and integrase complexes

31 March 2020

1 reference

Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity

31 March 2020

1 reference

Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism

31 March 2020

1 reference

Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

31 March 2020

1 reference

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).

31 March 2020

1 reference

Effect of HIV integrase inhibitors on the RAG1/2 recombinase

31 March 2020

1 reference

Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

31 March 2020

1 reference

Human immunodeficiency virus integration protein expressed in Escherichia coli possesses selective DNA cleaving activity

31 March 2020

1 reference

A rapid in vitro assay for HIV DNA integration

31 March 2020

1 reference

A novel assay for the DNA strand-transfer reaction of HIV-1 integrase

31 March 2020

1 reference

A high-throughput, non-radioactive microtiter plate assay for activity of the human immunodeficiency virus integrase protein

31 March 2020

1 reference

HIV-1 integrase inhibitors: a decade of research and two drugs in clinical trial

31 March 2020

1 reference

Small-molecule HIV-1 integrase inhibitors: the 2001-2002 update

31 March 2020

1 reference

Novel inhibitors of HIV-1 integration.

31 March 2020

1 reference

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

31 March 2020

1 reference

New class of HIV integrase inhibitors that block viral replication in cell culture

31 March 2020

1 reference

Azido-containing diketo acid derivatives inhibit human immunodeficiency virus type 1 integrase in vivo and influence the frequency of deletions at two-long-terminal-repeat-circle junctions

31 March 2020

1 reference

Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents

31 March 2020

1 reference

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

31 March 2020

1 reference

Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

31 March 2020

1 reference

Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells

31 March 2020

1 reference

Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro

31 March 2020

1 reference

Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives

31 March 2020

1 reference

Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture

31 March 2020

1 reference

Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

31 March 2020

1 reference

Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

31 March 2020

1 reference

Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds

31 March 2020

1 reference

Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures

31 March 2020

1 reference

Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

31 March 2020

1 reference

Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

31 March 2020

1 reference

Thiazolothiazepine inhibitors of HIV-1 integrase

31 March 2020

1 reference

Thalassiolins A-C: new marine-derived inhibitors of HIV cDNA integrase

31 March 2020

1 reference

Metal-dependent inhibition of HIV-1 integrase

31 March 2020

1 reference

Inhibition of human immunodeficiency virus type-1 integrase by curcumin

31 March 2020

1 reference

Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin

31 March 2020

1 reference

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design

31 March 2020

1 reference

Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor

31 March 2020

1 reference

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

31 March 2020

1 reference

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells

31 March 2020

1 reference

Structural determinants for HIV-1 integrase inhibition by beta-diketo acids

31 March 2020

1 reference

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

31 March 2020

1 reference

Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors

31 March 2020

1 reference

Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes

31 March 2020

1 reference

Fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc finger protein E2C direct integration of viral DNA into specific sites

31 March 2020

1 reference

Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition

31 March 2020

1 reference

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA

31 March 2020

1 reference

Differential inhibition of HIV-1 preintegration complexes and purified integrase protein by small molecules

31 March 2020

1 reference

Integration complexes derived from HIV vectors for rapid assays in vitro

31 March 2020

1 reference

HMG protein family members stimulate human immunodeficiency virus type 1 and avian sarcoma virus concerted DNA integration in vitro

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Resistance to the anti-human immunodeficiency virus type 1 compound L-chicoric acid results from a single mutation at amino acid 140 of integrase

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1660

1 reference

1 August 2017

1 reference

PubMed ID

15729361