Presenilin 1 (Q4377404)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49768

Presenilin ER Ca2+ Leak Channel

1 reference

Transporter Classification Database ID

1.A.54.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

9 May 2019

Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

beta-catenin binding

protein binding

13 references

9 May 2019

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Cellular localization of Nicastrin affects amyloid beta species production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Activation and intrinsic γ-secretase activity of presenilin 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Intracellular trafficking of TREM2 is regulated by presenilin 1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

calcium channel activity

1 reference

9 May 2019

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

aspartic-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

1 reference

31 January 2017

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

aspartic endopeptidase activity, intramembrane cleaving

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

endopeptidase activity

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

aspartic-type endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49768&geneProductId=UniProtKB:P49768

3 references

1 January 2018

1 January 2018

Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49768&geneProductId=UniProtKB:P49768

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49768&geneProductId=UniProtKB:P49768

1 January 2018

beta-catenin binding

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

aspartic endopeptidase activity, intramembrane cleaving

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell component

nuclear membrane

1 reference

9 May 2019

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

membrane

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

ciliary rootlet

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron projection

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

nucleus

2 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

31 January 2017

kinetochore

1 reference

9 May 2019

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

centrosome

1 reference

9 May 2019

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

rough endoplasmic reticulum

1 reference

9 May 2019

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

dendritic shaft

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

aggresome

1 reference

9 May 2019

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell surface

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

membrane-bounded organelle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

4 references

31 January 2017

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

31 January 2017

Two homologous genes causing early-onset familial Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

31 January 2017

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

6 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Two homologous genes causing early-onset familial Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

9 May 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

growth cone

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

neuromuscular junction

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

intracellular anatomical structure

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

axon

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

nuclear outer membrane

1 reference

9 May 2019

Two homologous genes causing early-onset familial Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

Golgi membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

integral component of plasma membrane

1 reference

31 January 2017

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

smooth endoplasmic reticulum

lysosomal membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

dendrite

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

presynapse

1 reference

31 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

mitochondrial inner membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cytoplasmic vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cytoplasm

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell cortex

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

integral component of membrane

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

azurophil granule membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

Z discdkac

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

1 reference

31 January 2017

soma

2 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

31 January 2017

perinuclear region of cytoplasm

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

1 reference

31 January 2017

nucleus

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

5 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Two homologous genes causing early-onset familial Alzheimer's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

synaptic vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

growth cone

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

3 references

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

sarcolemma

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron projection

soma

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

synapse

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

synaptic membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

integral component of presynaptic membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

early endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

negative regulation of neuron apoptotic process

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

somitogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of MAP kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of catalytic activity

1 reference

9 May 2019

Purification and characterization of the human gamma-secretase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

mitochondrial transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

post-embryonic development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of dendritic spine development

1 reference

9 May 2019

Role of presenilin1 in structural plasticity of cortical dendritic spines in vivo

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cellular response to DNA damage stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

heart looping

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

blood vessel development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

regulation of epidermal growth factor-activated receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

regulation of resting membrane potential

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

regulation of synaptic transmission, glutamatergic

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

amyloid precursor protein catabolic process

3 references

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

thymus development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of coagulation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of apoptotic signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

memory

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

endoplasmic reticulum calcium ion homeostasis

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

3 references

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

31 January 2017

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

response to oxidative stress

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

autophagosome assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

development of the heart

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of axonogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

embryonic limb morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

locomotion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

learning or memory

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

protein transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cerebral cortex cell migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

L-glutamate transmembrane transport

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

brain morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of protein phosphorylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

myeloid leukocyte differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

synaptic vesicle targeting

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

Cajal-Retzius cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

skin morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of protein kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell fate specification

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

skeletal system morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

regulation of phosphorylation

1 reference

9 May 2019

Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cellular calcium ion homeostasis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

epithelial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron migration

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of transcription by RNA polymerase II

1 reference

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

regulation of synaptic plasticity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of epidermal growth factor-activated receptor activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

hematopoietic progenitor cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cerebral cortex development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P49768

1 reference

31 January 2017

dorsal/ventral neural tube patterning

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neural retina development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of protein kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

T cell activation involved in immune response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neurogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

protein processing

3 references

protein maturation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

myeloid dendritic cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

autophagy

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

protein glycosylation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

brain development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of ubiquitin-protein transferase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

choline transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49768&geneProductId=UniProtKB:P49768

negative regulation of ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

forebrain development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

regulation of protein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

T cell receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

segmentation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of receptor recycling

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

calcium ion transmembrane transport

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

amyloid precursor protein metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neutrophil degranulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

positive regulation of L-glutamate import across plasma membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

astrocyte activation involved in immune response

1 reference

9 May 2019

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

learning or memory

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

regulation of neuron projection development

1 reference

9 May 2019

A novel highly pathogenic Alzheimer presenilin-1 mutation in codon 117 (Pro117Ser): Comparison of clinical, neuropathological and cell culture phenotypes of Pro117Leu and Pro117Ser mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cerebellum development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of protein binding

1 reference

9 May 2019

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

endoplasmic reticulum calcium ion homeostasis

G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

Notch receptor processing, ligand-dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

positive regulation of phosphorylation

1 reference

9 May 2019

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of apoptotic process

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

9 May 2019

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

astrocyte activation

1 reference

9 May 2019

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

amyloid-beta metabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

synapse organization

1 reference

9 May 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cell-cell adhesion

1 reference

9 May 2019

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

cellular response to amyloid-beta

1 reference

9 May 2019

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid-β

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of core promoter binding

1 reference

9 May 2019

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

negative regulation of low-density lipoprotein receptor activity

1 reference

9 May 2019

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

positive regulation of amyloid fibril formation

1 reference

9 May 2019

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

neuron projection maintenance

1 reference

9 May 2019

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

membrane protein intracellular domain proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

positive regulation of protein import into nucleus

1 reference

9 May 2019

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

ephrin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

1 reference

9 May 2019

positive regulation of gene expression

negative regulation of gene expression

positive regulation of glycolytic process

1 reference

9 May 2019

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

6978

English

17 August 2016

Gene Atlas image

PBB GE PSEN1 203460 s at fs.png
732 × 530; 12 KB

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

1.A.54.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database