A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling (Q30828170)

14 September 2017

A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling (English)

1 reference

14 September 2017

7

1 reference

14 September 2017

5

George Q Daley

0 references

Ferenc A. Scheeren

object named as

Ferenc Scheeren

series ordinal

3

0 references

Hergen Spits

series ordinal

6

object named as

Hergen Spits

1 reference

14 September 2017

1

Avi Shvarts

1 reference

14 September 2017

Thijn R Brummelkamp

2

1 reference

PMCID

155362

14 September 2017

Eugene Koh

series ordinal

4

1 reference

PMCID

155362

14 September 2017

language of work or name

English

0 references

publication date

1 March 2002

1 reference

14 September 2017

1 reference

14 September 2017

16

1 reference

14 September 2017

6

1 reference

14 September 2017

681-686

1 reference

Gene expression profiling predicts clinical outcome of breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Specific protection against breast cancers by cyclin D1 ablation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Cellular senescence: mitotic clock or culture shock?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

The molecular and cellular origins of Hodgkin's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

p14ARF links the tumour suppressors RB and p53.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Expression of the BCL6 gene in the pre- and postnatal mouse

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

MDMX: a novel p53-binding protein with some functional properties of MDM2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

mdm2 expression is induced by wild type p53 activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Conditional transformation of mouse liver epithelial cells. An in vitro model for analysis of genetic events in hepatocarcinogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=155362

Common-variable immunodeficiency-related lymphomas associate with mutations and rearrangements of BCL-6: Pathogenetic and histogenetic implications

25 November 2018

1 reference

12 December 2020

Association of human cyclin E with a periodic G1-S phase protein kinase

1 reference

12 December 2020

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

1 reference

12 December 2020

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

12 December 2020

p16 INK4a can initiate an autonomous senescence program

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.929302

1 reference

14 September 2017

1 reference

14 September 2017

1 reference

PMCID

155362