A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment (Q28651094)

22

0 references

Adam D. Lillicrap

Adam Lillicrap

30

0 references

Till Luckenbach

Till Luckenbach

31

0 references

José María Navas

José M. Navas

33

0 references

Stefan Scholz

Stefan Scholz

1

0 references

Eberhard Küster

Eberhard Küster

29

0 references

Guillermo Repetto

Guillermo Repetto

35

0 references

Scott E. Belanger

Scott Belanger

13

0 references

Ludek Blaha

Ludek Blaha

3

0 references

Gerrit Schüürmann

Gerrit Schüürmann

37

0 references

Mauricio García-Franco

Mauricio García-Franco

6

0 references

Willie Peijnenburg

Willie Peijnenburg

34

0 references

Emilio Benfenati

14

Emilio Benfenati

0 references

Knut Erik Tollefsen

39

Knut Erik Tollefsen

0 references

Kristin Schirmer

9

Kristin Schirmer

0 references

James Wheeler

42

James R. Wheeler

0 references

Katrin Tanneberger

10

Katrin Tanneberger

0 references

Thomas Braunbeck

4

Thomas Braunbeck

0 references

Albertinka J Murk

32

Albertinka J. Murk

0 references

author name string

Erika Sela

2

0 references

Malyka Galay-Burgos

5

0 references

Joaquin Guinea

7

0 references

Nils Klüver

8

0 references

Marysia Tobor-Kapłon

11

0 references

Hilda Witters

12

0 references

Stuart Creton

15

0 references

Mark T.D. Cronin

16

0 references

Rik I.L. Eggen

17

0 references

Michelle Embry

18

0 references

Drew Ekman

19

0 references

Anne Gourmelon

20

0 references

Marlies Halder

21

0 references

Thomas Hartung

23

0 references

Bruno Hubesch

24

0 references

Dirk Jungmann

25

0 references

Mark A. Lampi

26

0 references

Lucy Lee

27

0 references

Marc Léonard

28

0 references

Edward Salinas

36

0 references

Horst Spielmann

38

0 references

Susanne Walter-Rohde

40

0 references

Graham Whale

41

0 references

Matthew J. Winter

Regulatory Toxicology and Pharmacology

43

0 references

language of work or name

English

0 references

publication date

December 2013

0 references

published in

0 references

volume

67

0 references

page(s)

506-530

0 references

issue

3

0 references

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Challenging the requirement for chronic fish toxicity studies on formulated plant protection products.

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A Stepwise Approach for Defining the Applicability Domain of SAR and QSAR Models

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The fish embryo toxicity test as an animal alternative method in hazard and risk assessment and scientific research

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Efflux transporters: newly appreciated roles in protection against pollutants

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Protein and lipid binding parameters in rainbow trout (Oncorhynchus mykiss) blood and liver fractions to extrapolate from an in vitro metabolic degradation assay to in vivo bioaccumulation potential of hydrophobic organic chemicals

7 January 2021

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Automatic knowledge extraction from chemical structures: the case of mutagenicity prediction

7 January 2021

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Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption.

7 January 2021

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Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos

7 January 2021

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Constitutive mRNA expression and protein activity levels of nine ABC efflux transporters in seven permanent cell lines derived from different tissues of rainbow trout (Oncorhynchus mykiss).

7 January 2021

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Toxic concentrations in fish early life stages peak at a critical moment.

7 January 2021

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Screening for (anti)androgenic properties using a standard operation protocol based on the human stably transfected androgen sensitive PALM cell line. First steps towards validation

7 January 2021

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Revisiting bioaccumulation criteria for POPs and PBT assessments

7 January 2021

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Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

7 January 2021

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Dynamics of BNF-induced in vivo ethoxyresorufin-O-deethylase (EROD) activity during embryonic development of medaka (Oryzias latipes)

7 January 2021

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Evolutionary conservation of human drug targets in organisms used for environmental risk assessments.

7 January 2021

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Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).

7 January 2021

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Collaborative development of predictive toxicology applications

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Integrated testing strategies for safety assessments

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Chemical regulators have overreached

7 January 2021

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An overview of values for the threshold of toxicological concern

7 January 2021

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Alternative approaches can greatly reduce the number of fish used for acute toxicity testing

7 January 2021

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Variability of in vivo fish acute toxicity data

7 January 2021

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A strategy to reduce the numbers of fish used in acute ecotoxicity testing of pharmaceuticals.

7 January 2021

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Bad habits die hard: the NOEC's persistence reflects poorly on ecotoxicology.

7 January 2021

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A strategy to reduce the use of fish in acute ecotoxicity testing of new chemical substances notified in the European Union

7 January 2021

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Use of TSHβ:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals

7 January 2021

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Chicken embryo cardiomyocyte cultures--a new approach for studying effects of halogenated aromatic hydrocarbons in the avian heart

7 January 2021

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Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity

7 January 2021

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Environmental effect assessment for sexual endocrine-disrupting chemicals: Fish testing strategy

7 January 2021

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Predicting Adult Fish Acute Lethality with the Zebrafish Embryo: Relevance of Test Duration, Endpoints, Compound Properties, and Exposure Concentration Analysis

7 January 2021

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Mutual acceptance of data: harmonised test methods and quality assurance of data--the process explained

7 January 2021

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Rapid behavior-based identification of neuroactive small molecules in the zebrafish

7 January 2021

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Development of a partition-controlled dosing system for cell assays

7 January 2021

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The influence of modes of action and physicochemical properties of chemicals on the correlation between in vitro and acute fish toxicity data

7 January 2021

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Adverse outcome pathways and ecological risk assessment: bridging to population-level effects

7 January 2021

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The threshold of toxicological concern concept in risk assessment

7 January 2021

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7 January 2021

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7 January 2021

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Development of a flow-through system for the fish embryo toxicity test (FET) with the zebrafish (Danio rerio).

7 January 2021

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Well past time to stop using NOELs and LOELs.

7 January 2021

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Validation of the target lipid model for toxicity assessment of residual petroleum constituents: monocyclic and polycyclic aromatic hydrocarbons.

7 January 2021

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New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors.

7 January 2021

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Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations.

7 January 2021

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Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

7 January 2021

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In vitro-in vivo extrapolation of quantitative hepatic biotransformation data for fish. I. A review of methods, and strategies for incorporating intrinsic clearance estimates into chemical kinetic models

7 January 2021

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Non destructive in vivo measurement of ethoxyresorufin biotransformation by zebrafish prolarva: development and application

7 January 2021

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Transgenic zebrafish illuminate the dynamics of thyroid morphogenesis and its relationship to cardiovascular development

7 January 2021

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Baseline characteristics and statistical implications for the OECD 210 fish early-life stage chronic toxicity test

7 January 2021

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Guidance for evaluating in vivo fish bioaccumulation data

7 January 2021

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Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value.

7 January 2021

1 reference

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Determinants of variability in acute to chronic toxicity ratios for aquatic invertebrates and fish.

7 January 2021

1 reference

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Use of avian lymphocytes to detect toxicity: effects of a commonly utilized deltamethrin preparation.

7 January 2021

1 reference

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PETROTOX: an aquatic toxicity model for petroleum substances

7 January 2021

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Physicochemical substance properties as indicators for unreliable exposure in microplate-based bioassays.

7 January 2021

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A European pharmaceutical company initiative challenging the regulatory requirement for acute toxicity studies in pharmaceutical drug development.

7 January 2021

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The OSIRIS Weight of Evidence approach: ITS for skin sensitisation.

7 January 2021

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Can we reduce the number of fish in the OECD acute toxicity test?

7 January 2021

1 reference

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Identification of a critical dose level for risk assessment: developments in benchmark dose analysis of continuous endpoints

7 January 2021

1 reference

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Proposal to improve vertebrate cell cultures to establish them as substitutes for the regulatory testing of chemicals and effluents using fish

7 January 2021

1 reference

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Methodology for demonstrating and measuring the photocytotoxicity of fluoranthene to fish cells in culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Transcriptomics in ecotoxicology

7 January 2021

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TOX 21: new dimensions of toxicity testing

7 January 2021

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Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians--screening for estrogen, androgen and thyroid hormone disruption.

7 January 2021

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Epoxide and thiirane toxicity in vitro with the ciliates Tetrahymena pyriformis: structural alerts indicating excess toxicity.

7 January 2021

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How to deal with lipophilic and volatile organic substances in microtiter plate assays

7 January 2021

1 reference

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A novel in vitro system for the determination of bioconcentration factors and the internal dose in zebrafish (Danio rerio) eggs

7 January 2021

1 reference

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Using the fish plasma model for comparative hazard identification for pharmaceuticals in the environment by extrapolation from human therapeutic data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Quantitative read-across for predicting the acute fish toxicity of organic compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Prediction of Michael-Type Acceptor Reactivity toward Glutathione

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Cross-sector review of drivers and available 3Rs approaches for acute systemic toxicity testing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Assessment of the developmental neurotoxicity of compounds by measuring locomotor activity in zebrafish embryos and larvae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Controlling and maintaining exposure of hydrophobic organic compounds in aquatic toxicity tests by passive dosing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Passive dosing for producing defined and constant exposure of hydrophobic organic compounds during in vitro toxicity tests

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Paradigm shift in toxicity testing and modeling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Use of the up-and-down acute toxicity test procedure to generate LC50 data for fish

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Predicting fish acute toxicity using a fish gill cell line-based toxicity assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Effects of solvents and dosing procedure on chemical toxicity in cell-based in vitro assays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Assessment of metabolic capabilities of PLHC-1 and RTL-W1 fish liver cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Predictive Value of Species Sensitivity Distributions for Effects of Herbicides in Freshwater Ecosystems

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Investigating alternatives to the fish early-life stage test: a strategy for discovering and annotating adverse outcome pathways for early fish development

7 January 2021

1 reference

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Vision & strategy: Predictive ecotoxicology in the 21st century.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Adverse outcome pathways during early fish development: a conceptual framework for identification of chemical screening and prioritization strategies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Structural AlertsA New Classification Model to Discriminate Excess Toxicity from Narcotic Effect Levels of Organic Compounds in the Acute Daphnid Assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Effects of perfluoroalkyl compounds on mRNA expression levels of thyroid hormone-responsive genes in primary cultures of avian neuronal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Zebrafish teratogenicity test with metabolic activation (mDarT): effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Zebrafish (Danio rerio) embryos as a model for testing proteratogens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Developmental effects of coumarin and the anticoagulant coumarin derivative warfarin on zebrafish (Danio rerio) embryos.

7 January 2021

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Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

The state of in vitro science for use in bioaccumulation assessments for fish

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Refinement of the ECETOC approach to identify endocrine disrupting properties of chemicals in ecotoxicology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Test concentration setting for fish in vivo endocrine screening assays

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Application of chemical toxicity distributions to ecotoxicology data requirements under REACH.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

The assessment of estrogenic or anti-estrogenic activity of chemicals by the human stably transfected estrogen sensitive MELN cell line: results of test performance and transferability

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

The role of the European Chemicals Bureau in promoting the regulatory use of (Q)SAR methods†

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

Promises and pitfalls of quantitative structure-activity relationship approaches for predicting metabolism and toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003

On the number of EINECS compounds that can be covered by (Q)SAR models for acute toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.10.003