The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS). (Q46859198)

25 December 2017

title

The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS). (English)

1 reference

25 December 2017

author

Ralph Kühne

8

1 reference

25 December 2017

Gerrit Schüürmann

9

1 reference

25 December 2017

Eduard Pauné

object named as

Eduard Pauné

6

0 references

Harrie Buist

object named as

Harrie Buist

4

0 references

author name string

Inga Tluczkiewicz

1

1 reference

25 December 2017

Monika Batke

2

1 reference

25 December 2017

Dinant Kroese

3

1 reference

25 December 2017

Tom Aldenberg

5

1 reference

25 December 2017

Helvi Grimm

7

1 reference

25 December 2017

Inge Mangelsdorf

10

1 reference

25 December 2017

Sylvia E Escher

11

1 reference

25 December 2017

language of work or name

English

0 references

publication date

21 February 2013

1 reference

25 December 2017

Regulatory Toxicology and Pharmacology

published in

1 reference

25 December 2017

volume

67

1 reference

25 December 2017

issue

2

1 reference

25 December 2017

page(s)

157-169

1 reference

25 December 2017

Evaluation of time extrapolation factors based on the database RepDose

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Relevance of non-guideline studies for risk assessment: the coverage model based on most frequent targets in repeated dose toxicity studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Structure alerts for carcinogenicity, and the Salmonella assay system: a novel insight through the chemical relational databases technology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

REPDOSE: A database on repeated dose toxicity studies of commercial chemicals--A multifunctional tool

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Acute and chronic toxicity toward the bacteria Vibrio fischeri of organic narcotics and epoxides: structural alerts for epoxide excess toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Structural alerts for the excess toxicity of acrylates, methacrylates, and propiolates derived from their short-term and long-term bacterial toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Thiol reactivity and its impact on the ciliate toxicity of α,β-unsaturated aldehydes, ketones, and esters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

A tiered approach to threshold of regulation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Estimation of toxic hazard—A decision tree approach

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Evaluation of inhalation TTC values with the database RepDose

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Refining the threshold of toxicological concern (TTC) for risk prioritization of trace chemicals in food.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Development of a decision support system for the introduction of alternative methods into local irritancy/corrosivity testing strategies. Creation of fundamental rules for a decision support system.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

An alternative approach for the safety evaluation of new and existing chemicals, an exercise in integrated testing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Towards optimization of chemical testing under REACH: a Bayesian network approach to Integrated Testing Strategies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Computational evidence for α-nitrosamino radical as initial metabolite for both the P450 dealkylation and denitrosation of carcinogenic nitrosamines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Estimation of Compartmental Half-lives of Organic Compounds – Structural Similarityversus EPI-Suite

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Chemical domain of QSAR models from atom-centered fragments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Subacute toxicity of hexachlorobenzene in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

A structured approach to Exposure Based Waiving of human health endpoints under REACH developed in the OSIRIS project

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Predicting Michael-acceptor reactivity and toxicity through quantum chemical transition-state calculations.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

"ToxRTool", a new tool to assess the reliability of toxicological data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Epoxide and thiirane toxicity in vitro with the ciliates Tetrahymena pyriformis: structural alerts indicating excess toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Quantitative read-across for predicting the acute fish toxicity of organic compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Chemoassay screening of DNA-reactive mutagenicity with 4-(4-nitrobenzyl)pyridine - application to epoxides, oxetanes, and sulfur heterocycles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Improvement of the Cramer classification for oral exposure using the database TTC RepDose--a strategy description

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

Local Electrophilicity Predicts the Toxicity-Relevant Reactivity of Michael Acceptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2013.02.004

10.1016/J.YRTPH.2013.02.004

7 January 2021

Identifiers

DOI

1 reference

25 December 2017

release_tu7ynqyitvfzxdpsc6sdfex5cm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tu7ynqyitvfzxdpsc6sdfex5cm

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

23439429

1 reference

25 December 2017