The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing (Q27062617)

17

affiliation

Karolinska Institutet

0 references

Roland Grafström

7

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Pekka Kohonen

1

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Rebecca Ceder

4

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Barry Hardy

19

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Vedrin Jeliazkov

11

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Christoph Helma

Christoph Helma

9

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Lyn Healy

Lyn Healy

8

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Emilio Benfenati

2

Emilio Benfenati

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Glenn Myatt

14

Glenn Myatt

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Glyn N. Stacey

16

Glyn Stacey

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author name string

David Bower

3

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Michael Crump

5

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Kevin Cross

6

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Silvia Maggioni

12

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Scott Miller

13

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Michael Rautenberg

15

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Jeff Wiseman

Open PHACTS: semantic interoperability for drug discovery

18

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publication date

January 2013

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number of pages

17

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published in

Molecular Informatics

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volume

32

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issue

1

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page(s)

47-63

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Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model

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Screening of repeated dose toxicity data present in SCC(NF)P/SCCS safety evaluations of cosmetic ingredients

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Concise review: Human pluripotent stem cell-based models for cardiac and hepatic toxicity assessment

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Standardization of pluripotent stem cell cultures for toxicity testing

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Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue

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Systems chemical biology and the Semantic Web: what they mean for the future of drug discovery research

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Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action

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Differential effects of iodoacetamide and iodoacetate on glycolysis and glutathione metabolism of cultured astrocytes.

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The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: A stopped-flow kinetic study

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Systems analysis of protein modification and cellular responses induced by electrophile stress

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Drug metabolite profiling and elucidation of drug-induced hepatotoxicity

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A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells.

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Reaction of aflatoxin B(1) oxidation products with lysine

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Metabolism of simple quinones in guinea pig and rat cardiac tissue

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Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines

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NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels

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Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.

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Mechanisms of acetaminophen-induced liver necrosis

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Thermodynamic and kinetic considerations for the reaction of semiquinone radicals to form superoxide and hydrogen peroxide

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Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation

21 January 2018

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Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model

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Anti-schizophrenic drugs—Membrane receptor sites of action

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Drug-induced phospholipidosis

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Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

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Acrolein causes transcriptional induction of phase II genes by activation of Nrf2 in human lung type II epithelial (A549) cells

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Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism

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The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

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Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.

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Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation

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The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity

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A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells.

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A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system

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The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions

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Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

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Tissue repair: an important determinant of final outcome of toxicant-induced injury

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Experimental model of hepatic fibrosis following repeated periportal necrosis induced by allylalcohol

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Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration

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Liver fibrosis in patients with psoriasis and psoriatic arthritis on long-term, high cumulative dose methotrexate therapy

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Toward a better understanding of methotrexate

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Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate

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Mechanism of carbon tetrachloride-induced hepatotoxicity. Hepatocellular damage by reactive carbon tetrachloride metabolites.

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The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies

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Identifiers

DOI

10.1002/MINF.201200114

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1995028

Fatcat ID

release_e7txn4l3avdw7aln4k5h6fy2ou

0 references

OpenCitations bibliographic resource ID

1995028

1 reference