Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation (Q28590575)

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31 January 2017

A. Loehr

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31 January 2017

Y. Zhang

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31 January 2017

J. Kim

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31 January 2017

M. Henkemeyer

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31 January 2017

A. Cashen

Neurofibromatosis and cancer.

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31 January 2017

language of work or name

English

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publication date

5 August 1999

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31 January 2017

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31 January 2017

18

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31 January 2017

4450–4459

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31 January 2017

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31 January 2017

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Regulators and Effectors of ras Proteins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Identification and characterization of the neurofibromatosis type 1 protein product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Increased expression of the neurofibromatosis 1 (NF1) gene product, neurofibromin, in astrocytes in response to cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Proliferation of human malignant astrocytomas is dependent on Ras activation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Identification of the neurofibromatosis type 1 gene product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Precocious puberty in children with neurofibromatosis type 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Expression of neurofibromin, the neurofibromatosis 1 gene product: studies in human neuroblastoma cells and rat brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The proliferative response of astrocytes to injury in neonatal rat brain. A combined immunocytochemical and autoradiographic study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Mutation and cancer: statistical study of retinoblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Optic gliomas in children with neurofibromatosis type 1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Brainstem tumors in patients with neurofibromatosis type 1: a distinct clinical entity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Expression of the neurofibromatosis I gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Expression of the neurofibromatosis 1 (NF1) gene during growth arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The management of brainstem gliomas in patients with neurofibromatosis 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Astroglial proliferation and phenotype are modulated by neuronal plasma membrane.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

C17, a retrovirally immortalized neuronal cell line, inhibits the proliferation of astrocytes and astrocytoma cells by a contact-mediated mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021

The neurofibromatosis type 1 gene encodes a protein related to GAP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829

7 January 2021