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Neurofibromin 1 (Q21987763)

From Wikidata
mammalian protein found in Mus musculus
  • neurofibromin
  • neurofibromatosis-related protein NF-1
  • Nf1
  • neurofibromatosis 1
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    English
    Neurofibromin 1
    mammalian protein found in Mus musculus
    • neurofibromin
    • neurofibromatosis-related protein NF-1
    • Nf1
    • neurofibromatosis 1

    Statements

    molecular function
    GTPase activator activity
    determination method or standard
    IGI
    IEA
    IMP
    ISO
    7 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    ISO
    retrieved
    8 April 2019
    stated in
    Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    Q04690
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IEA
    cell component
    biological process
    negative regulation of Ras protein signal transduction
    determination method or standard
    IGI
    IMP
    7 references
    retrieved
    8 April 2019
    stated in
    Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Neurofibromin plays a critical role in modulating osteoblast differentiation of mesenchymal stem/progenitor cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    Ras protein signal transduction
    determination method or standard
    IGI
    IMP
    7 references
    retrieved
    8 April 2019
    stated in
    The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1 has an essential role in endothelial cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    negative regulation of cell population proliferation
    determination method or standard
    IGI
    IMP
    18 references
    retrieved
    8 April 2019
    stated in
    Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Mouse models of tumor development in neurofibromatosis type 1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Analysis of melanocyte precursors in Nf1 mutants reveals that MGF/KIT signaling promotes directed cell migration independent of its function in cell survival
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Mouse tumor model for neurofibromatosis type 1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    development of the heart
    determination method or standard
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Nf1 has an essential role in endothelial cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    negative regulation of cell migration
    determination method or standard
    IGI
    IEA
    IMP
    ISO
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    ISO
    retrieved
    8 April 2019
    stated in
    Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IEA
    visual learning
    determination method or standard
    IGI
    IMP
    5 references
    retrieved
    8 April 2019
    stated in
    Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IMP
    retrieved
    8 April 2019
    stated in
    Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    A mouse model for the learning and memory deficits associated with neurofibromatosis type I
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI
    retrieved
    8 April 2019
    stated in
    The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04690
    determination method or standard
    IGI

    Identifiers

     
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