Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria (Q28507255)

B cell leukemia/lymphoma 2

GOA release 2020-03-11

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

GOA release 2020-03-11

1 reference

O. Teijido

1

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24 January 2017

L. Dejean

series ordinal

2

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24 January 2017

language of work or name

English

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publication date

4 August 2010

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24 January 2017

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24 January 2017

584

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24 January 2017

15

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24 January 2017

3305–3310

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24 January 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

BCL-2 family proteins: critical checkpoints of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

A tale of two mitochondrial channels, MAC and PTP, in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Mitochondrial membrane permeabilization in cell death

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Mitochondria as the target of the pro-apoptotic protein Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Is MAC the knife that cuts cytochrome c from mitochondria during apoptosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Novel murine B-cell lymphoma/leukemia model to study BCL2-driven oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Regulated targeting of BAX to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

A novel, high conductance channel of mitochondria linked to apoptosis in mammalian cells and Bax expression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Diagnosing and exploiting cancer's addiction to blocks in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Oligomeric Bax is a component of the putative cytochrome c release channel MAC, mitochondrial apoptosis-induced channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Assembly of the mitochondrial apoptosis-induced channel, MAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Pathways of apoptosis in lymphocyte development, homeostasis, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bax activation and mitochondrial insertion during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bcl-XL inhibits membrane permeabilization by competing with Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

A potent cell death activity associated with transient high level expression of BCL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Bax inserts into the mitochondrial outer membrane by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

The mitochondrial TOM complex modulates bax-induced apoptosis in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

A short Nur77-derived peptide converts Bcl-2 from a protector to a killer

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002

BAX activation is initiated at a novel interaction site

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.07.002