B cell leukemia/lymphoma 2 (Q14863583)

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mammalian protein found in Mus musculus
  • apoptosis regulator Bcl-2
  • uniprot:P10417
  • Bcl2
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Language Label Description Also known as
English
B cell leukemia/lymphoma 2
mammalian protein found in Mus musculus
  • apoptosis regulator Bcl-2
  • uniprot:P10417
  • Bcl2

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
14 February 2019
stated in
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
GOA
curator
UniProt
UniProt protein ID
P10417
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
GOA
curator
UniProt
UniProt protein ID
P10417
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
BID: a novel BH3 domain-only death agonist
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Endogenous HMGB1 regulates autophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
IAN family critically regulates survival and development of T lymphocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Cyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein Bim
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Upregulation of Bcl2 inhibits apoptosis-driven BAX insertion but favors BAX relocalization in mitochondria
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Deacetylation of p53 induces autophagy by suppressing Bmf expression
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
protein heterodimerization activity
determination method
IPI
IEA
ISO
6 references
retrieved
27 February 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
27 February 2018
stated in
BID: a novel BH3 domain-only death agonist
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
27 February 2018
stated in
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
27 February 2018
stated in
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IEA
protein heterodimerization activity
determination method
IBA
IEA
IPI
ISO
7 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
BID: a novel BH3 domain-only death agonist
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IPI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IBA
cell component
mitochondrion
determination method
IDA
IEA
ISO
8 references
retrieved
27 February 2018
stated in
The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P10417
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
27 February 2018
stated in
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Expression of Bcl-2 protein in murine neural cells in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
A mitochondrial protein compendium elucidates complex I disease biology
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
nucleus
determination method
IDA
IEA
ISO
7 references
retrieved
14 February 2019
stated in
Role of BCL-2 in the survival and function of developing and mature sympathetic neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P10417
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Bcl-2 protein expression during murine development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Expression of Bcl-2 protein in murine neural cells in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
mitochondrion
determination method
HDA
IDA
IEA
ISO
8 references
retrieved
14 February 2019
stated in
The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P10417
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
Sorting specificity of spermatogenic cell specific region of mouse hexokinase-s (mHk1-s)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Expression of Bcl-2 protein in murine neural cells in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
HDA
retrieved
14 February 2019
stated in
A mitochondrial protein compendium elucidates complex I disease biology
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
HDA
biological process
negative regulation of neuron apoptotic process
determination method
IDA
IEA
IMP
ISO
7 references
retrieved
14 February 2019
stated in
Role of BCL-2 in the survival and function of developing and mature sympathetic neurons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Patterns of cell death in mouse anteroventral cochlear nucleus neurons after unilateral cochlea removal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
post-embryonic development
determination method
IGI
IMP
7 references
retrieved
14 February 2019
stated in
bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Hair follicle apoptosis and Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IGI
retrieved
14 February 2019
stated in
Bcl-2 and Bax function independently to regulate cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IGI
apoptotic process
determination method
IEA
IMP
ISO
6 references
retrieved
14 February 2019
stated in
Bcl-2 prevents hippocampal cell death induced by the neuroleptic drug haloperidol
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P10417
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
kidney development
determination method
IGI
IMP
10 references
retrieved
14 February 2019
stated in
bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Polycystic kidney disease prevented by transgenic RNA interference
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IGI
retrieved
14 February 2019
stated in
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IGI
retrieved
14 February 2019
stated in
Bcl-2 and Bax function independently to regulate cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IGI
negative regulation of apoptotic process
determination method
ISS
IEA
IGI
IDA
IMP
ISO
29 references
retrieved
27 February 2018
stated in
Proapoptotic BAX and BAK control multiple initiator caspases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISS
retrieved
27 February 2018
stated in
Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
27 February 2018
stated in
Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Diminished cell proliferation associated with the death-protective activity of Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
27 February 2018
stated in
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IGI
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
27 February 2018
stated in
Regulation of the lifespan in dendritic cell subsets
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Apoptosis and Bcl-2 expression in cultured murine splenic T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Bax directly induces release of cytochrome c from isolated mitochondria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
27 February 2018
stated in
Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P10417&geneProductId=UniProtKB:P10417
determination method
IDA
negative regulation of apoptotic process
determination method
IBA
IDA
IEA
IGI
IMP
ISO
ISS
30 references
retrieved
14 February 2019
stated in
Proapoptotic BAX and BAK control multiple initiator caspases
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISS
retrieved
14 February 2019
stated in
Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
ISO
retrieved
14 February 2019
stated in
Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Diminished cell proliferation associated with the death-protective activity of Bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Susceptibility of cerebellar granule neurons derived from Bcl-2-deficient and transgenic mice to cell death
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Bcl-2 is required for cranial sensory neuron survival at defined stages of embryonic development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IMP
retrieved
14 February 2019
stated in
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IGI
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IEA
retrieved
14 February 2019
stated in
Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Targeted Disruption of the PDZK1 Gene in Mice Causes Tissue-specific Depletion of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I and Altered Lipoprotein Metabolism
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Bax directly induces release of cytochrome c from isolated mitochondria
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Apoptosis and Bcl-2 expression in cultured murine splenic T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Regulation of the lifespan in dendritic cell subsets
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10417
determination method
IBA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q14863583&oldid=2023060070"