Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage (Q28304131)

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M Shiraga

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H Kato

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S Honda

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M Sako

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Y Kurata

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Y Kanakura

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Y Tomiyama

Journal of Thrombosis and Haemostasis

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language of work or name

English

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publication date

February 2005

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published in

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volume

3

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page(s)

361-8

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issue

2

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cites work

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WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

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Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

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IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

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Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

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The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling

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Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility

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Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail

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Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold

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Arp2/3 complex is required for actin polymerization during platelet shape change

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Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice

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WAVE2 is required for directed cell migration and cardiovascular development

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WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility

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Wiskott-Aldrich syndrome protein and platelets

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WASP and N-WASP in human platelets differ in sensitivity to protease calpain

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Activation of integrin alpha IIb beta 3 in the glycoprotein Ib-high population of a megakaryocytic cell line, CMK, by inside-out signaling

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Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling

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The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin.

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Differential localization of WAVE isoforms in filopodia and lamellipodia of the neuronal growth cone

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Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity

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Expression of WASP and Scar1/WAVE1 actin-associated proteins is differentially modulated during differentiation of HL-60 cells

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Differential Roles of WAVE1 and WAVE2 in Dorsal and Peripheral Ruffle Formation for Fibroblast Cell Migration

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Development of platelet inhibition by cAMP during megakaryocytopoiesis

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