Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck (Q28218186)

Gene Ontology release 2020-05-02

Sharon Eden

1

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Rajat Rohatgi

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Alexandre V Podtelejnikov

3

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Matthias Mann

4

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Marc W Kirschner

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

5

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publication date

15 August 2002

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language of work or name

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418

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issue

6899

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page(s)

790-3

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cites work

1 reference

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

21 April 2017

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Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

21 April 2017

1 reference

Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

21 April 2017

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

21 April 2017

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WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

21 April 2017

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Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

21 April 2017

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Increased apoptosis induction by 121F mutant p53

21 April 2017

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In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

21 April 2017

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A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P

21 April 2017

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Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck

21 April 2017

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Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease

21 April 2017

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The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis

21 April 2017

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IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

21 April 2017

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Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels

21 April 2017

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The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42

21 April 2017

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Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility

21 April 2017

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Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.

21 April 2017

1 reference

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How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

21 January 2018

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Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

21 January 2018

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Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00859

p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00859

Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00859

Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00859

Scar/WAVE is localised at the tips of protruding lamellipodia in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00859

inferred from DOI database lookup

7 January 2021

based on heuristic

Purification of muscle actin

1 reference

https://api.crossref.org/works/10.1038%2FNATURE00859