Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold (Q24290178)

GOA release 2020-03-11

WASP family member 1

1 reference

GOA release 2020-03-11

3

N M Alto

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author name string

R S Westphal

1

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S H Soderling

2

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L K Langeberg

4

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J D Scott

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

5

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language of work or name

English

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publication date

1 September 2000

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published in

The EMBO Journal

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volume

19

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page(s)

4589-600

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issue

17

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cites work

1 reference

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Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex

19 March 2017

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WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

19 March 2017

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19 March 2017

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Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

19 March 2017

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Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase

19 March 2017

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Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain

19 March 2017

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The molecular basis for protein kinase A anchoring revealed by solution NMR

19 March 2017

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Rho GTPases and the actin cytoskeleton

19 March 2017

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Actin-binding verprolin is a polarity development protein required for the morphogenesis and function of the yeast actin cytoskeleton

19 March 2017

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Signaling through scaffold, anchoring, and adaptor proteins

19 March 2017

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GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex

19 March 2017

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Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding

19 March 2017

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Interaction between Wiskott-Aldrich Syndrome protein (WASP) and the Fyn protein-tyrosine kinase

19 March 2017

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The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization

19 March 2017

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19 March 2017

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

7 April 2017

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Integrins regulate the association and phosphorylation of paxillin by c-Abl

19 March 2017

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Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain

19 March 2017

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Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains

19 March 2017

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Identification of Itk/Tsk Src homology 3 domain ligands

19 March 2017

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Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif

19 March 2017

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Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled

19 March 2017

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N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

19 March 2017

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SH2 and SH3 domains: from structure to function

7 April 2017

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How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

7 April 2017

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Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins

27 September 2017

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AKAPs: from structure to function

27 September 2017

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27 September 2017

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cAMP-dependent growth cone guidance by netrin-1.

27 September 2017

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Nuclear tyrosine kinases: from Abl to WEE1.

27 September 2017

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Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.

27 September 2017

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Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate.

27 September 2017

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enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties.

27 September 2017

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Activation of tyrosinase kinase and microfilament-binding functions of c-abl by bcr sequences in bcr/abl fusion proteins

27 September 2017

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Blotting and band-shifting: techniques for studying protein-protein interactions

27 September 2017

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The identification of Bruton's tyrosine kinase and Wiskott-Aldrich syndrome protein associated proteins and signalling pathways.

27 September 2017

1 reference

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Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

27 September 2017

1 reference

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The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance.

30 May 2018

1 reference

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Overlay, ligand blotting, and band-shift techniques to study kinase anchoring.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=302050

cAMP-induced switching in turning direction of nerve growth cones.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=302050

Mutational analysis of the A-kinase anchoring protein (AKAP)-binding site on RII. Classification Of side chain determinants for anchoring and isoform selective association with AKAPs.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=302050

Activation of the small GTP-binding proteins rho and rac by growth factor receptors.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=302050

Assay of cyclic AMP-dependent protein kinases

30 May 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10970852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/19.17.4589

1 reference

4855779

4855779

1 reference

1 reference

1 reference