The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease (Q28254943)

ubiquitin-proteasome system

Europe PubMed Central

title

The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer's Disease (English)

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main subject

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1 reference

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Klaus Heese

2

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author name string

Yanuar Alan Sulistio

series ordinal

1

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language of work or name

English

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publication date

March 2016

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published in

Molecular Neurobiology

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volume

53

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issue

2

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page(s)

905-31

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cites work

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Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

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α-Cleavage of cellular prion protein

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A disintegrin and metalloproteases: molecular scissors in angiogenesis, inflammation and atherosclerosis

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ADAM family proteins in the immune system

21 January 2018

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Shedding light on ADAM metalloproteinases

21 January 2018

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Implication of APP secretases in notch signaling

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

21 January 2018

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The ADAMs family: coordinators of nervous system development, plasticity and repair

21 January 2018

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A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

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Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease

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ADAM17 as a therapeutic target in multiple diseases.

21 January 2018

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ADAM17, shedding, TACE as therapeutic targets

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ADAM17: a molecular switch to control inflammation and tissue regeneration

21 January 2018

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Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

A secreted form of human ADAM9 has an alpha-secretase activity for APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Brain site-specific gene expression analysis in Alzheimer's disease patients

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The Alzheimer's peptides Abeta40 and 42 adopt distinct conformations in water: a combined MD / NMR study

21 January 2018

1 reference

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Characterizations of distinct amyloidogenic conformations of the Abeta (1-40) and (1-42) peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Nuclear signalling by membrane protein intracellular domains: the AICD enigma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

21 January 2018

1 reference

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Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The AICD interacting protein DAB1 is up-regulated in Alzheimer frontal cortex brain samples and causes deregulation of proteins involved in gene expression changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

AICD nuclear signaling and its possible contribution to Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid beta protein enhances the survival of hippocampal neurons in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid

21 January 2018

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Neurogenic effect of beta-amyloid peptide in the development of neural stem cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

21 January 2018

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In vitro and in vivo protein oxidation induced by Alzheimer's disease amyloid beta-peptide (1-42).

21 January 2018

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Temporal relations among amyloid beta-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

21 January 2018

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Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide

21 January 2018

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Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Lipid oxidation and peroxidation in CNS health and disease: from molecular mechanisms to therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Link between oxidative stress and acute brain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Hydrogen peroxide mediates amyloid beta protein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Resistance of human cerebrospinal fluid to in vitro oxidation is directly related to its amyloid-beta content

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Oxidative stress hypothesis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Alzheimer's disease and amyloid: culprit or coincidence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau protein pathology in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

REVIEW: tau protein pathology in Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau alteration and neuronal degeneration in tauopathies: mechanisms and models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

A protein factor essential for microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tubulin requires tau for growth onto microtubule initiating sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The distribution of tau in the mammalian central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Suppression of MAP2 in cultured cerebellar macroneurons inhibits minor neurite formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau is required for neurite outgrowth and growth cone motility of chick sensory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Axonal transport defects in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Role of axonal transport in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau proteins: the molecular structure and mode of binding on microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Role of tau protein in both physiological and pathological conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau phosphorylation and aggregation in Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Phosphorylation of human Tau protein by microtubule affinity-regulating kinase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Calcium signaling and amyloid toxicity in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Intrinsically disordered proteins in the neurodegenerative processes: formation of tau protein paired helical filaments and their analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Prion-like properties of pathological TDP-43 aggregates from diseased brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Spliceosome integrity is defective in the motor neuron diseases ALS and SMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Prion-like transmission of protein aggregates in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Alzheimer's pathogenesis: is there neuron-to-neuron propagation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Cell-to-cell transmission of non-prion protein aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Cell biology. A unifying role for prions in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The propagation of prion-like protein inclusions in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Transmission and spreading of tauopathy in transgenic mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Propagation of tau misfolding from the outside to the inside of a cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Prion-like spreading of pathological α-synuclein in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Misfolded protein aggregates: mechanisms, structures and potential for disease transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Prions hijack tunnelling nanotubes for intercellular spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Brain site-specific proteome changes in aging-related dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Ubiquitin-proteasome system as a modulator of cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Protein homeostasis and aging: role of ubiquitin protein ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Ubiquitin: structures, functions, mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The ubiquitin system: pathogenesis of human diseases and drug targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

TRIM family proteins: retroviral restriction and antiviral defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

TRIM proteins and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Molecular Pathways of Neurodegeneration in Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Proteasome activator enhances survival of Huntington's disease neuronal model cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

A role for ubiquitin in selective autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Autophagy gone awry in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Autophagy failure in Alzheimer's disease--locating the primary defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The Hsp70 and Hsp60 chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Molecular chaperone functions in protein folding and proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The heat shock response: life on the verge of death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Hsp70 chaperones: cellular functions and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Hsp70 chaperone dynamics and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Protein rescue from aggregates by powerful molecular chaperone machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

FKBP immunophilins and Alzheimer's disease: a chaperoned affair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Structure-based classification of 45 FK506-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

FKBP family proteins: immunophilins with versatile biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Structure of human peptidyl-prolylcis-transisomerase FKBP22 containing two EF-hand motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Reconstructing the Hsp90/Tau Machine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Immunophilins and their ligands: insights into survival and growth of human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

A peptidyl-prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid peptide attenuates the proteasome activity in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Abeta inhibits the proteasome and enhances amyloid and tau accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The neuroprotective actions of FK506 binding protein ligands: neuronal survival is triggered by de novo RNA synthesis, but is independent of inhibition of JNK and calcineurin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

O1-06-04: Methylthioninium chloride (MTC) acts as a Tau aggregation inhibitor (TAI) in a cellular model and reverses Tau pathology in transgenic mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

RING domain E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Targeting FKBP isoforms with small-molecule ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

The intracellular domain of amyloid precursor protein interacts with FKBP12

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-014-9063-4

Emerging therapeutics for Alzheimer's disease

21 January 2018

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus

1 reference

12 December 2020

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

1 reference

12 December 2020

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1 reference

12 December 2020

Impaired proteasome function in Alzheimer's disease

1 reference

12 December 2020

The subcellular distribution of FK506 binding proteins in rat brain

1 reference

12 December 2020

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

12 December 2020

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1 reference

12 December 2020

Plasma levels of amyloid beta proteins Abeta1-40 and Abeta1-42(43) are elevated in Down's syndrome

1 reference

12 December 2020

A putative role of the Amyloid Precursor Protein Intracellular Domain (AICD) in transcription.

1 reference

12 December 2020

A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage

1 reference

12 December 2020

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1 reference

12 December 2020

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

12 December 2020

Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis

1 reference

12 December 2020

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state

1 reference

12 December 2020

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

1 reference

12 December 2020

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs

1 reference

12 December 2020

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

1 reference

12 December 2020

Apolipoprotein E and Alzheimer's disease

1 reference

12 December 2020

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

12 December 2020

Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner

1 reference

12 December 2020

Hypoxia-induced lipid peroxidation in the brain during postnatal ontogenesis.

1 reference

12 December 2020

2013 Alzheimer's disease facts and figures

1 reference

12 December 2020

Diverse distribution and function of fibrous microtubule-associated proteins in the nervous system.

1 reference

12 December 2020

Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

1 reference

12 December 2020

Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer's disease

1 reference

12 December 2020

Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene

1 reference

12 December 2020

Binding of amyloid beta protein to the 20 S proteasome

1 reference

12 December 2020

The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types

1 reference

12 December 2020

Abeta40 promotes neuronal cell fate in neural progenitor cells

1 reference

12 December 2020

Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro

1 reference

12 December 2020

Proteasome degradation of brain cytosolic tau in Alzheimer's disease

1 reference

12 December 2020

Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein

1 reference

12 December 2020

Altered expression of genes for amyloid and cytoskeletal proteins in Alzheimer cortex

1 reference

12 December 2020

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease

1 reference

12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments

1 reference

12 December 2020

Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress

1 reference

12 December 2020

Mass spectrometry of purified amyloid beta protein in Alzheimer's disease

1 reference

12 December 2020

Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton

1 reference

12 December 2020

Defective ubiquitination of cerebral proteins in Alzheimer's disease

1 reference

12 December 2020

The immunophilin ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in the substantia nigra pars compacta following transection of the rat medial forebrain bundle

1 reference

12 December 2020

1 reference

12 December 2020

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

1 reference

12 December 2020

Prion-like mechanisms in neurodegenerative diseases

1 reference

12 December 2020

APOE ε4: the most prevalent yet understudied risk factor for Alzheimer's disease

1 reference

12 December 2020