Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex (Q27683886)

Exosome non-catalytic core subunit RRP4 YHR069C

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Exosome non-catalytic core subunit RRP45 YDR280W

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Exosome non-catalytic core subunit RRP46 YGR095C

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Exosome non-catalytic core subunit RRP40 YOL142W

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Exosome non-catalytic core subunit SKI6 YGR195W

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Exosome non-catalytic core subunit RRP43 YCR035C

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Exosome non-catalytic core subunit RRP42 YDL111C

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Exosome non-catalytic core subunit MTR3 YGR158C

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The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases

author

Elena Conti

series ordinal

3

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author name string

Debora Lika Makino

series ordinal

1

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Marc Baumgärtner

series ordinal

2

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language of work or name

English

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publication date

7 March 2013

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published in

Nature

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volume

495

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issue

7439

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page(s)

70-5

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cites work

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The archaeal exosome core is a hexameric ring structure with three catalytic subunits

22 April 2017

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Reconstitution, activities, and structure of the eukaryotic RNA exosome

22 April 2017

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Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core

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Insights into the mechanism of progressive RNA degradation by the archaeal exosome

22 April 2017

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Crystal structure of Caulobacter crescentus polynucleotide phosphorylase reveals a mechanism of RNA substrate channelling and RNA degradosome assembly

22 April 2017

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A single subunit, Dis3, is essentially responsible for yeast exosome core activity

22 April 2017

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The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

22 April 2017

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Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family

22 April 2017

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The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation

22 April 2017

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Endonucleolytic RNA cleavage by a eukaryotic exosome

22 April 2017

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The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities.

22 April 2017

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The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome

22 April 2017

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Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing

22 April 2017

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RNA channelling by the eukaryotic exosome

22 April 2017

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Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8 S rRNA 3' end formation

22 April 2017

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Evidence for core exosome independent function of the nuclear exoribonuclease Rrp6p

22 April 2017

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RNA channelling by the archaeal exosome

22 April 2017

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NIH Image to ImageJ: 25 years of image analysis

22 April 2017

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Structural and biochemical characterization of the yeast exosome component Rrp40

22 April 2017

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Phasercrystallographic software

22 April 2017

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Overview of the CCP4 suite and current developments

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Coot: model-building tools for molecular graphics

22 April 2017

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Electrostatics of nanosystems: application to microtubules and the ribosome

22 April 2017

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ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

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The many pathways of RNA degradation

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https://api.crossref.org/works/10.1038%2FNATURE11870

Transcriptome-wide analysis of exosome targets

22 April 2017

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12 December 2020

Binding hot spots in the TEM1-BLIP interface in light of its modular architecture

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12 December 2020

Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1

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12 December 2020

Reconstitution of RNA exosomes from human and Saccharomyces cerevisiae cloning, expression, purification, and activity assays.

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12 December 2020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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12 December 2020

Self-compartmentalizing proteases.

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12 December 2020

Unravelling the dynamics of RNA degradation by ribonuclease II and its RNA-bound complex.

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12 December 2020

Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.

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12 December 2020

Origins and activities of the eukaryotic exosome.

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12 December 2020

Structural framework for the mechanism of archaeal exosomes in RNA processing

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12 December 2020

The Leishmania tarentolae exosome: Purification and structural analysis by electron microscopy

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12 December 2020