Exosome non-catalytic core subunit SKI6 YGR195W (Q27550280)

Ribosomal protein S5 domain 2-type fold

1 reference

PNPase/RNase PH domain superfamily

1 reference

Exoribonuclease, phosphorolytic domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

Exoribonuclease, phosphorolytic domain 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

1 reference

9 May 2019

protein binding

15 references

9 May 2019

Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Subunit architecture of multimeric complexes isolated directly from cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

A single subunit, Dis3, is essentially responsible for yeast exosome core activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

A comprehensive two-hybrid analysis to explore the yeast protein interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Structure of an Rrp6–RNA exosome complex bound to poly(A) RNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Probing genuine strong interactions and post-translational modifications in the heterogeneous yeast exosome protein complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

RNA channelling by the eukaryotic exosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

RNA degradation paths in a 12-subunit nuclear exosome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

The archaeal exosome core is a hexameric ring structure with three catalytic subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

molecular function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

1 reference

9 May 2019

ND

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

1 reference

9 May 2019

nuclear exosome (RNase complex)

exosome (RNase complex)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

1 reference

9 May 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

1 reference

9 May 2019

cytoplasmic exosome (RNase complex)

nuclear exosome (RNase complex)

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

cytoplasmic exosome (RNase complex)

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Comparative multiplexed mass spectrometric analyses of endogenously expressed yeast nuclear and cytoplasmic exosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

biological process

nonfunctional rRNA decay

1 reference

9 May 2019

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

polyadenylation-dependent snoRNA 3'-end processing

1 reference

27 March 2018

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46948&geneProductId=UniProtKB:P46948

rRNA catabolic process

1 reference

27 March 2018

Functions of the exosome in rRNA, snoRNA and snRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46948&geneProductId=UniProtKB:P46948

nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay

Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

U4 snRNA 3'-end processing

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46948&geneProductId=UniProtKB:P46948

27 March 2018

Functions of the exosome in rRNA, snoRNA and snRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46948&geneProductId=UniProtKB:P46948

27 March 2018

Functions of the exosome in rRNA, snoRNA and snRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46948&geneProductId=UniProtKB:P46948

nuclear polyadenylation-dependent CUT catabolic process

1 reference

9 May 2019

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

nuclear mRNA surveillance

nuclear polyadenylation-dependent mRNA catabolic process

1 reference

9 May 2019

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

nuclear-transcribed mRNA catabolic process, non-stop decay

1 reference

9 May 2019

The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

1 reference

27 March 2018

The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P46948&geneProductId=UniProtKB:P46948

rRNA processing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

1 reference

9 May 2019

nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'

U4 snRNA 3'-end processing

Functions of the exosome in rRNA, snoRNA and snRNA synthesis

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Functions of the exosome in rRNA, snoRNA and snRNA synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

nuclear mRNA surveillance

Identification of a regulated pathway for nuclear pre-mRNA turnover.

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Identification of a regulated pathway for nuclear pre-mRNA turnover.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46948

Exoribonuclease, phosphorolytic domain 1

has part(s)

1 reference

Exoribonuclease, phosphorolytic domain 2

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference