Structure of a presenilin family intramembrane aspartate protease (Q27683614)

6

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author name string

Xiaochun Li

1

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Shangyu Dang

2

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Chuangye Yan

3

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Xinqi Gong

4

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Jiawei Wang

Identification of an archaeal presenilin-like intramembrane protease

5

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language of work or name

English

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publication date

3 January 2013

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published in

Nature

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volume

493

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page(s)

56-61

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issue

7430

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cites work

1 reference

12 December 2020

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

1 reference

12 December 2020

Substructure solution with SHELXD

1 reference

12 December 2020

Automated MAD and MIR structure solution

1 reference

12 December 2020

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

1 reference

12 December 2020

How intramembrane proteases bury hydrolytic reactions in the membrane.

1 reference

12 December 2020

Phasercrystallographic software

1 reference

12 December 2020

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

12 December 2020

Crystal structure of a rhomboid family intramembrane protease.

1 reference

12 December 2020

Three-dimensional structure of the signal peptide peptidase

1 reference

12 December 2020

Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

1 reference

12 December 2020

Prediction of membrane protein structures with complex topologies using limited constraints

1 reference

12 December 2020

X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

1 reference

12 December 2020

Toward the structural genomics of complexes: Crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis

1 reference

12 December 2020

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

1 reference

12 December 2020

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

1 reference

12 December 2020

Three-dimensional structure of the γ-secretase complex

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

12 December 2020

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

12 December 2020

SOLVE and RESOLVE: automated structure solution, density modification and model building

1 reference

12 December 2020

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

1 reference

12 December 2020

Structure of a site-2 protease family intramembrane metalloprotease

1 reference

12 December 2020

Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo

1 reference

12 December 2020

Improvement of molecular-replacement models with Sculptor

1 reference

12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

12 December 2020

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

12 December 2020

Protein structure comparison by alignment of distance matrices

1 reference

12 December 2020

PHENIX: a comprehensive Python-based system for macromolecular structure solution

1 reference

12 December 2020

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

12 December 2020

Completion of autobuilt protein models using a database of protein fragments

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

12 December 2020

PHENIX: building new software for automated crystallographic structure determination

1 reference

12 December 2020

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.

1 reference

12 December 2020

The crystal structure of the rhomboid peptidase from Haemophilus influenzae provides insight into intramembrane proteolysis

1 reference

12 December 2020

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

1 reference

12 December 2020

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase

1 reference

12 December 2020

The crystal structure of GXGD membrane protease FlaK

1 reference

12 December 2020

Evidence that the "NF" motif in transmembrane domain 4 of presenilin 1 is critical for binding with PEN-2.

1 reference

12 December 2020

The CCP4 suite: programs for protein crystallography

1 reference

12 December 2020

Presenilin: running with scissors in the membrane

1 reference

12 December 2020

Identification of a novel family of presenilin homologues

1 reference

12 December 2020

Coot: model-building tools for molecular graphics

1 reference

12 December 2020

Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms

1 reference

12 December 2020

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

1 reference

12 December 2020

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

1 reference

12 December 2020

OCTOPUS: improving topology prediction by two-track ANN-based preference scores and an extended topological grammar

1 reference

12 December 2020

Structural investigation of the C-terminal catalytic fragment of presenilin 1

1 reference

12 December 2020

Active gamma-secretase complexes contain only one of each component

1 reference

12 December 2020

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

12 December 2020

A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis

1 reference

12 December 2020

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

12 December 2020

Structural basis for intramembrane proteolysis by rhomboid serine proteases

1 reference

12 December 2020

Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE11801

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE11801

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

4027498

1003146650

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4027498

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference