Prion pathogenesis in the absence of NLRP3/ASC inflammasomes (Q27316552)

April 2022 Public Data File from Crossref

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The physical relationship between infectivity and prion protein aggregates is strain-dependent

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

21 March 2017

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The immunobiology of prion diseases

28 September 2017

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SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells

28 September 2017

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28 September 2017

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Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia

28 September 2017

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28 September 2017

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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

28 September 2017

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Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35.

28 September 2017

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The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

28 September 2017

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Protective role of interferon regulatory factor 3-mediated signaling against prion infection.

28 September 2017

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Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila.

28 September 2017

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Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner

28 September 2017

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Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1.

28 September 2017

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Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo

28 September 2017

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The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases

28 September 2017

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Prions: protein aggregation and infectious diseases

28 September 2017

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The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes

28 September 2017

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Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice

28 September 2017

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Genes contributing to prion pathogenesis

28 September 2017

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A versatile prion replication assay in organotypic brain slices

28 September 2017

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Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection

28 September 2017

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Insights into prion strains and neurotoxicity

28 September 2017

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Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection.

28 September 2017

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Role of interleukin-1 in prion disease-associated astrocyte activation

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324825

Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324825

Prion pathogenesis in the absence of Toll-like receptor signalling

28 September 2017

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Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease

28 September 2017

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Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324825

Microglia from Creutzfeldt-Jakob disease-infected brains are infectious and show specific mRNA activation profiles

28 September 2017

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Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

28 September 2017

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Microglial activation varies in different models of Creutzfeldt-Jakob disease.

28 September 2017

1 reference

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Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

28 September 2017

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Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acute-phase response gene expression in scrapie

28 September 2017

1 reference

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Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K.

28 September 2017

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Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta

31 May 2018

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Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324825

Relationship of microglia and scrapie amyloid-immunoreactive plaques in kuru, Creutzfeldt-Jakob disease and Gerstmann-Sträussler syndrome.

31 May 2018

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Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

31 May 2018

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Microglia is a component of the prion protein amyloid plaque in the Gerstmann-Sträussler-Scheinker syndrome.

31 May 2018

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PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie.

21 January 2018

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The role of cytokines, astrocytes, microglia and apoptosis in Creutzfeldt-Jakob disease.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0117208

Absence of detectable IL-1beta production in murine prion disease: a model of chronic neurodegeneration.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0117208

IL-1 family members as candidate genes modulating scrapie susceptibility in sheep: localization, partial characterization, and expression.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0117208

Antibody-mediated inhibition of integrin α5β1 blocks neurotoxic prion peptide PrP106-126-induced activation of BV2 microglia

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0117208

Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt-Jakob disease

21 January 2018

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12 December 2020

Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice

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12 December 2020

Sporadic Creutzfeldt-Jakob disease: the extent of microglia activation is dependent on the biochemical type of PrPSc

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12 December 2020

Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease

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12 December 2020

Response to local inflammation of IL-1 beta-converting enzyme- deficient mice

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12 December 2020