Regulation of CD95/Fas signaling at the DISC (Q26824629)

P H Krammer

series ordinal

2

1 reference

language of work or name

1 reference

January 2012

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Cell Death & Differentiation

published in

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volume

19

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issue

1

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page(s)

36-41

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The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations

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The Fas-FADD death domain complex structure unravels signalling by receptor clustering

7 April 2017

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Yes and PI3K bind CD95 to signal invasion of glioblastoma

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Caspases: pharmacological manipulation of cell death

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7 April 2017

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Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

7 April 2017

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FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis

7 April 2017

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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

7 April 2017

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Inhibition of death receptor signals by cellular FLIP

7 April 2017

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The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

7 April 2017

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Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

7 April 2017

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CD95's deadly mission in the immune system

7 April 2017

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

7 April 2017

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The role of c-FLIP in modulation of CD95-induced apoptosis

7 April 2017

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FLICE is activated by association with the CD95 death-inducing signaling complex (DISC).

7 April 2017

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

7 April 2017

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Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

7 April 2017

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

7 April 2017

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

7 April 2017

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Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

7 April 2017

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

22 April 2017

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Two CD95 (APO-1/Fas) signaling pathways

7 April 2017

1 reference

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Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity

7 April 2017

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Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL.

28 September 2017

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Systems biology of apoptosis signaling networks

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

Dynamics within the CD95 death-inducing signaling complex decide life and death of cells

28 September 2017

1 reference

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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

28 September 2017

1 reference

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Understanding apoptosis by systems biology approaches

28 September 2017

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XIAP discriminates between type I and type II FAS-induced apoptosis

28 September 2017

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Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice

28 September 2017

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CD95 stimulation results in the formation of a novel death effector domain protein-containing complex

28 September 2017

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Life and death in peripheral T cells

28 September 2017

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Analysis of CD95 threshold signaling: triggering of CD95 (FAS/APO-1) at low concentrations primarily results in survival signaling

28 September 2017

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Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

28 September 2017

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cFLIP regulation of lymphocyte activation and development

28 September 2017

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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand

28 September 2017

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The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

28 September 2017

1 reference

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

28 September 2017

1 reference

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c-FLIPR, a new regulator of death receptor-induced apoptosis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury.

28 September 2017

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Interdimer processing mechanism of procaspase-8 activation.

28 September 2017

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The death domain superfamily: a tale of two interfaces?

28 September 2017

1 reference

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An induced proximity model for caspase-8 activation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3252827

A new C-terminal cleavage product of procaspase-8, p30, defines an alternative pathway of procaspase-8 activation

31 May 2018

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

31 May 2018

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A novel domain within the 55 kd TNF receptor signals cell death

31 May 2018

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Monoclonal antibody-mediated tumor regression by induction of apoptosis.

31 May 2018

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Control of neuronal branching by the death receptor CD95 (Fas/Apo-1).

19 June 2018

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The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

21 January 2018

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Role of proteolysis in caspase-8 activation and stabilization

21 January 2018

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Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2011.155

The active caspase-8 heterotetramer is formed at the CD95 DISC

21 January 2018

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https://api.crossref.org/works/10.1038%2FCDD.2011.155

The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation.

21 January 2018

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The CD95 Receptor: Apoptosis Revisited

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22075988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fas engagement induces neurite growth through ERK activation and p35 upregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22075988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of fas death signals by FLIPs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22075988

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDD.2011.155

1 reference

Dimensions Publication ID

472016

1047006678

0 references

Fatcat ID

release_itf3ijzt3vc5vjg7vkxpercasq

0 references

472016

1 reference

1 reference

1 reference