cFLIP regulation of lymphocyte activation and development (Q36405075)

14 August 2017

title

cFLIP regulation of lymphocyte activation and development (English)

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14 August 2017

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3

Jürg Tschopp

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14 August 2017

1

Ralph C Budd

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14 August 2017

Wen-Chen Yeh

2

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14 August 2017

publication date

1 March 2006

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Nature Reviews Immunology

14 August 2017

language of work or name

English

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published in

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14 August 2017

volume

6

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14 August 2017

issue

3

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14 August 2017

page(s)

196-204

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publication type of scholarly work

14 August 2017

review article

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c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

cites work

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

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N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway

31 March 2020

1 reference

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

31 March 2020

1 reference

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

31 March 2020

1 reference

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

31 March 2020

1 reference

A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

31 March 2020

1 reference

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

31 March 2020

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The modular nature of apoptotic signaling proteins

31 March 2020

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Inhibition of death receptor signals by cellular FLIP

31 March 2020

1 reference

Casper is a FADD- and caspase-related inducer of apoptosis

31 March 2020

1 reference

FLAME-1, a Novel FADD-like Anti-apoptotic Molecule That Regulates Fas/TNFR1-induced Apoptosis

31 March 2020

1 reference

CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis

31 March 2020

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CASH, a Novel Caspase Homologue with Death Effector Domains

31 March 2020

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MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX L and initiates cell death

31 March 2020

1 reference

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

31 March 2020

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Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex

31 March 2020

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Inhibition of fas death signals by FLIPs

31 March 2020

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c-FLIPR, a new regulator of death receptor-induced apoptosis.

31 March 2020

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Rapid turnover of c-FLIPshort is determined by its unique C-terminal tail

31 March 2020

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Caspases: the executioners of apoptosis

31 March 2020

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Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex

31 March 2020

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The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex

31 March 2020

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Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation

31 March 2020

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Caspase activation is required for T cell proliferation

31 March 2020

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Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

31 March 2020

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Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

31 March 2020

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The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

31 March 2020

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NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

31 March 2020

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Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds

31 March 2020

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CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells

31 March 2020

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Activation of NF-kappaB by FADD, Casper, and caspase-8.

31 March 2020

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Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities

31 March 2020

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Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase

31 March 2020

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A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

31 March 2020

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Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells

31 March 2020

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Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis

31 March 2020

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Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells

31 March 2020

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Fas engagement induces neurite growth through ERK activation and p35 upregulation

31 March 2020

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FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA

31 March 2020

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Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels.

31 March 2020

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FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes.

31 March 2020

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FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication

31 March 2020

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Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory res

31 March 2020

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Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages

31 March 2020

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Human CD34+ hematopoietic stem/progenitor cells express high levels of FLIP and are resistant to Fas-mediated apoptosis

31 March 2020

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FLIP is expressed in mouse testis and protects germ cells from apoptosis

31 March 2020

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Mitogen-activated protein kinase kinase antagonized fas-associated death domain protein-mediated apoptosis by induced FLICE-inhibitory protein expression

31 March 2020

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TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia

31 March 2020

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Bile Acid Regulation of C/EBPβ, CREB, and c-Jun Function, via the Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Pathways, Modulates the Apoptotic Response of Hepatocytes

31 March 2020

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Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis

31 March 2020

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Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells

31 March 2020

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Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).

31 March 2020

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Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers

31 March 2020

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Regulation of Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in thyroid carcinoma cells

31 March 2020

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The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

31 March 2020

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NF-kappaB signals induce the expression of c-FLIP.

31 March 2020

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

31 March 2020

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Transcription factors of the NFAT family: regulation and function

31 March 2020

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Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor

31 March 2020

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Nuclear factor of activated T cells balances angiogenesis activation and inhibition.

31 March 2020

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p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells

31 March 2020

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Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.

31 March 2020

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Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins

31 March 2020

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Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

31 March 2020

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Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.

31 March 2020

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Inhibition of TCR-induced CD8 T cell death by IL-12: regulation of Fas ligand and cellular FLIP expression and caspase activation by IL-12.

31 March 2020

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IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins

31 March 2020

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IL-4 and IL-10 inhibition of spontaneous monocyte apoptosis is associated with Flip upregulation

31 March 2020

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Inhibition of CD95 apoptotic signaling by interferon-gamma in human osteoarthritic chondrocytes is associated with increased expression of FLICE inhibitory protein.

31 March 2020

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IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism

31 March 2020

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Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates

31 March 2020

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Fas transduces activation signals in normal human T lymphocytes

31 March 2020

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TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator

31 March 2020

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TNF/TNFR family members in costimulation of T cell responses

31 March 2020

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

31 March 2020

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The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

31 March 2020

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Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis

31 March 2020

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Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation

31 March 2020

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Cellular FLIP (long isoform) overexpression in T cells drives Th2 effector responses and promotes immunoregulation in experimental autoimmune encephalomyelitis

31 March 2020

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An essential role for c-FLIP in the efficient development of mature T lymphocytes

31 March 2020

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Cellular FLICE-inhibitory protein is required for T cell survival and cycling

31 March 2020

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Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

31 March 2020

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A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

31 March 2020

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A Role for FADD in T Cell Activation and Development

31 March 2020

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The requirements for Fas-associated death domain signaling in mature T cell activation and survival

31 March 2020

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A dominant negative Fas-associated death domain protein mutant inhibits proliferation and leads to impaired calcium mobilization in both T-cells and fibroblasts

31 March 2020

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Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

31 March 2020

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Caspase-8 serves both apoptotic and nonapoptotic roles

31 March 2020

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Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-costimulated human T cells

31 March 2020

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Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.

31 March 2020

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CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.

31 March 2020

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FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

31 March 2020

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Fas Ligand Engagement of Resident Peritoneal Macrophages In Vivo Induces Apoptosis and the Production of Neutrophil Chemotactic Factors

31 March 2020

1 reference

Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

31 March 2020

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An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome

31 March 2020

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Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes

31 March 2020

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Regulation of the Fas death pathway by FLICE-inhibitory protein in primary human B cells

31 March 2020

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FLICE-inhibitory protein is a key regulator of germinal center B cell apoptosis

31 March 2020

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FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells.

31 March 2020

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Fas engagement accelerates liver regeneration after partial hepatectomy

31 March 2020

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Inhibition of death receptor signaling by FLICE-inhibitory protein as a mechanism for immune escape of tumors

31 March 2020

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The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors

31 March 2020

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Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

31 March 2020

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Heterogenous susceptibility to CD95-induced apoptosis in melanoma cells correlates with bcl-2 and bcl-x expression and is sensitive to modulation by interferon-gamma

31 March 2020

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

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The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system

31 March 2020

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Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium

31 March 2020

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NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis

31 March 2020

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WNT and beta-catenin signalling: diseases and therapies

31 March 2020

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Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling.

31 March 2020

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Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

31 March 2020

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Sequence and genomic analysis of a Rhesus macaque rhadinovirus with similarity to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1787

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Dimensions publication ID

14 August 2017

1038287527

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