CD95's deadly mission in the immune system (Q28142072)

Somatic generation of antibody diversity

Europe PubMed Central

title

CD95's deadly mission in the immune system (English)

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author name string

P H Krammer

series ordinal

1

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language of work or name

English

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publication date

12 October 2000

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published in

Nature

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volume

407

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issue

6805

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page(s)

789-95

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cites work

1 reference

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Selection of the T cell repertoire.

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How can dendritic cells cause autoimmune disease?

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Peripheral T-cell self-reactivity and immunological memory.

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A central role for thymic emigrants in peripheral T cell homeostasis

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CD95(APO-1/Fas)-mediated apoptosis: live and let die

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Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI

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Activation interferes with the APO-1 pathway in mature human T cells.

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Controlling cell death

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Cleavage of FLICE (caspase-8) by granzyme B during cytotoxic T lymphocyte-induced apoptosis

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Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteases

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Fas ligand in human serum

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Fas-mediated cytotoxicity--a new immunoregulatory and pathogenic function of Th1 CD4+ T cells

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Expression of the functional soluble form of human fas ligand in activated lymphocytes.

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Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing

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FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

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Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations

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A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

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Two CD95 (APO-1/Fas) signaling pathways

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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The pharmacology of T cell apoptosis

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

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A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis

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Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

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Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development

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TRAIL receptor-2 signals apoptosis through FADD and caspase-8

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

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T-cell apoptosis detected in situ during positive and negative selection in the thymus

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Thymocyte selection: not by TCR alone.

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The thymus and central tolerance

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FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

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When apoptosis fails.

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A role for Fas in negative selection of thymocytes in vivo

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Thymic dendritic cells express inducible nitric oxide synthase and generate nitric oxide in response to self- and alloantigens

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Biology of the interleukin-2 receptor

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Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

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Fas ligand mediates activation-induced cell death in human T lymphocytes

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Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

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Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.

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The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance

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The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

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Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death

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Induction of apoptosis in mature T cells by tumour necrosis factor

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Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts

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Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

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CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cells

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Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes

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Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo

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In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

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Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis

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bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

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Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts

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Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded

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TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation

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TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

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B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1

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The induction of tolerance by dendritic cells that have captured apoptotic cells

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

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Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

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CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells

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Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model.

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Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

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Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

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Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

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Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

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BCL-2 family: regulators of cell death

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Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector

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Activation of apoptosis pathways by anticancer drugs

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Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

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The role of APO-1-mediated apoptosis in the immune system

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Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein

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Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

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Programmed cell death as a mechanism of CD4 and CD8 T cell deletion in AIDS. Molecular control and effect of highly active anti-retroviral therapy

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Identifiers

DOI

10.1038/35037728

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1234284

1022325441

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1234284

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference