Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers (Q26781362)

PubMed

protein kinase inhibitors

28 September 2019

1 reference

PubMed

proto-oncogene proteins p21(ras)

2 October 2019

1 reference

19 July 2020

1 reference

26 August 2020

phosphoinositide-3 kinase inhibitor

2 references

30 January 2021

B-Raf proto-oncogene, serine/threonine kinase

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

author name string

Deborah Mukherji

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Ali Shamseddine

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

International Journal of Molecular Sciences

3 June 2020

language of work or name

English

0 references

publication date

23 September 2015

12 references

21 March 2019

3 April 2019

2 August 2019

28 September 2019

2 October 2019

20 November 2019

28 November 2019

18 December 2019

19 July 2020

26 August 2020

30 January 2021

9 October 2022

13 references

21 March 2019

3 April 2019

2 August 2019

28 September 2019

2 October 2019

20 November 2019

28 November 2019

18 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

19 July 2020

26 August 2020

30 January 2021

9 October 2022

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

22976-22988

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

3 June 2020

copyright license

12 references

21 March 2019

3 April 2019

2 August 2019

28 September 2019

2 October 2019

20 November 2019

28 November 2019

18 December 2019

19 July 2020

26 August 2020

30 January 2021

9 October 2022

0 references

on focus list of Wikimedia project

ScienceSource

0 references

cites work

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Effect of BRAF V600E mutation on tumor response of anti-EGFR monoclonal antibodies for first-line metastatic colorectal cancer treatment: a meta-analysis of randomized studies

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers

28 September 2017

1 reference

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Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer

28 September 2017

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28 September 2017

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28 September 2017

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Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy

28 September 2017

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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in precl

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

31 May 2018

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31 May 2018

1 reference

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31 May 2018

1 reference

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Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies

21 January 2018

1 reference

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Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).

21 January 2018

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Combine MEK inhibition with PI3K/mTOR inhibition exert inhibitory tumor growth effect on KRAS and PIK3CA mutation CRC xenografts due to reduced expression of VEGF and matrix metallopeptidase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS160922976

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

21 January 2018

1 reference

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The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

21 January 2018

1 reference

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A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26404261

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/IJMS160922976

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26404261%20AND%20SRC:MED&resulttype=core&format=json