Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models. (Q37349748)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24045180%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Overcoming IGF1R/IR resistance through inhibition of MEK signaling in colorectal cancer models (English)

1 reference

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22 February 2020

1 reference

1 reference

5

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22 February 2020

author name string

Sara A Flanigan

1

1 reference

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22 February 2020

Todd M Pitts

2

1 reference

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22 February 2020

Timothy P Newton

3

1 reference

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22 February 2020

Gillian N Kulikowski

4

1 reference

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22 February 2020

Martine C McManus

6

1 reference

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22 February 2020

Anna Spreafico

7

1 reference

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22 February 2020

Maria I Kachaeva

8

1 reference

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22 February 2020

Heather M Selby

9

1 reference

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22 February 2020

John J Tentler

10

1 reference

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22 February 2020

S Gail Eckhardt

11

1 reference

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22 February 2020

Stephen Leong

12

1 reference

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22 February 2020

language of work or name

English

0 references

publication date

17 September 2013

1 reference

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22 February 2020

published in

Clinical Cancer Research

1 reference

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22 February 2020

volume

19

1 reference

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22 February 2020

page(s)

6219-6229

1 reference

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22 February 2020

issue

22

1 reference

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Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models

22 February 2020

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Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor

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Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.

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Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.

6 September 2017

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Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy.

6 September 2017

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Targeted cancer therapies in the twenty-first century: lessons from imatinib

6 September 2017

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6 September 2017

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Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations

6 September 2017

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Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

6 September 2017

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Survivin: a new target for anti-cancer therapy

6 September 2017

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6 September 2017

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6 September 2017

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Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by suppression of the PI3K and NF-kappaB pathways

6 September 2017

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The role of the IGF system in cancer growth and metastasis: overview and recent insights

6 September 2017

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6 September 2017

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Overriding imatinib resistance with a novel ABL kinase inhibitor

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression

6 September 2017

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Combined inhibition of MEK and mTOR signaling inhibits initiation and progression of colorectal cancer

14 September 2017

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14 September 2017

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BRAF V600E disrupts AZD6244-induced abrogation of negative feedback pathways between extracellular signal-regulated kinase and Raf proteins

14 September 2017

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Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer

14 September 2017

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Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells.

14 September 2017

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14 September 2017

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Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

28 September 2017

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Antitumor activity of MEK and PI3K inhibitors against malignant pleural mesothelioma cells in vitro and in vivo

26 June 2018

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Blockade of MEK signaling potentiates 5-Aza-2'-deoxycytidine-induced apoptosis and upregulation of p21(waf1) in acute myelogenous leukemia cells.

2 September 2018

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Antitumor activity of GSK1904529A, a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase

2 September 2018

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The dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML.

2 September 2018

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Met acts on Mdm2 via mTOR to signal cell survival during development.

2 September 2018

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A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability.

2 September 2018

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Expression of insulin-like growth factor-1 receptor in human colorectal cancer

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24045180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Optimization of the sulforhodamine B colorimetric assay

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24045180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24045180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-13-0145

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24045180%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24045180%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference