APOE genotype and stress response - a mini review (Q26741633)

endoplasmic reticulum stress

20 November 2019

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8 August 2019

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20 August 2019

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12 October 2019

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20 November 2019

3

Almut Nebel

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author name string

Janina Dose

series ordinal

1

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Patricia Huebbe

series ordinal

2

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Gerald Rimbach

series ordinal

4

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language of work or name

English

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publication date

25 July 2016

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25 April 2019

17 June 2019

8 August 2019

20 August 2019

12 October 2019

19 November 2019

20 November 2019

Lipids in Health and Disease

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25 April 2019

17 June 2019

8 August 2019

20 August 2019

12 October 2019

19 November 2019

20 November 2019

15

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page(s)

121

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issue

1

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copyright license

Creative Commons Attribution 4.0 International

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25 April 2019

17 June 2019

8 August 2019

20 August 2019

12 October 2019

19 November 2019

on focus list of Wikimedia project

20 November 2019

copyright status

copyrighted

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ScienceSource

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exact match

https://scigraph.springernature.com/pub.10.1186/s12944-016-0288-2

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cites work

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

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Association of FOXO3A variation with human longevity confirmed in German centenarians

7 April 2017

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Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association

7 April 2017

1 reference

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HDL from CETP-deficient subjects shows enhanced ability to promote cholesterol efflux from macrophages in an apoE- and ABCG1-dependent pathway

7 April 2017

1 reference

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Mitochondrial and Ubiquitin Proteasome System Dysfunction in Ageing and Disease: Two Sides of the Same Coin?

7 April 2017

1 reference

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Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

7 April 2017

1 reference

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Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

7 April 2017

1 reference

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Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

7 April 2017

1 reference

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

7 April 2017

1 reference

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APOE ε4 is associated with higher vitamin D levels in targeted replacement mice and humans

7 April 2017

1 reference

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Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression

7 April 2017

1 reference

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APOE distribution in world populations with new data from India and the UK

7 April 2017

1 reference

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The distribution of apolipoprotein E alleles in Scottish perinatal deaths

7 April 2017

1 reference

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Non‐steroidal anti‐inflammatory drugs mediate increased in vitro glial expression of apolipoprotein E protein

7 April 2017

1 reference

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Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site

7 April 2017

1 reference

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Proteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challenge

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition

7 April 2017

1 reference

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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

7 April 2017

1 reference

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Mitochondria: in sickness and in health

7 April 2017

1 reference

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Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E

7 April 2017

1 reference

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Direct Transcriptional Effects of Apolipoprotein E

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

ApoE4 upregulates the activity of mitochondria-associated ER membranes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Cell cycle regulation of mitochondrial function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Influence of domain stability on the properties of human apolipoprotein E3 and E4 and mouse apolipoprotein E.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Cumulative effects of the ApoE genotype and gender on the synaptic proteome and oxidative stress in the mouse brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Immunosenescence, inflammation and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Extracellular proteolysis of apolipoprotein E (apoE) by secreted serine neuronal protease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Adenosine triphosphate concentrations are higher in the brain of APOE3- compared to APOE4-targeted replacement mice and can be modulated by curcumin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

When the dust settles: what did we learn from the bexarotene discussion?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Regulatory crosstalk within the mammalian unfolded protein response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

ApoE genotype: from geographic distribution to function and responsiveness to dietary factors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E genotype affects tissue metallothionein levels: studies in targeted gene replacement mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Cross-talk between apolipoprotein E and cytokines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Nrf2-dependent gene expression is affected by the proatherogenic apoE4 genotype-studies in targeted gene replacement mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Glycosylation and sialylation of macrophage-derived human apolipoprotein E analyzed by SDS-PAGE and mass spectrometry: evidence for a novel site of glycosylation on Ser290.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Implications of apolipoprotein E genotype on inflammation and vitamin E status

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Effects of hydrogen peroxide and apolipoprotein E isoforms on apolipoprotein E trafficking in HepG2 cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E limits oxidative stress-induced cell dysfunctions in human adipocytes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Alpha-tocopherol transport in the lung is affected by the apoE genotype--studies in transgenic apoE3 and apoE4 mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

From endoplasmic-reticulum stress to the inflammatory response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Gene-environment interaction and oxidative stress in cardiovascular disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E, an important player in longevity and age-related diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Impact of apoE genotype on oxidative stress, inflammation and disease risk

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

APOE genotype-specific differences in the innate immune response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Effects of apoE genotype on macrophage inflammation and heme oxygenase-1 expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Inflammatory networks in ageing, age-related diseases and longevity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Role of apolipoprotein E4 in protecting children against early childhood diarrhea outcomes and implications for later development

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E structure: insights into function.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

The quest for genetic determinants of human longevity: challenges and insights

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Does apolipoprotein E polymorphism influence susceptibility to malaria?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E: structure-function relationships

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

A CRISPR approach to gene targeting

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Effect of apoE genotype and dietary quercetin on blood lipids and TNF-alpha levels in apoE3 and apoE4 targeted gene replacement mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

The relationship between apolipoprotein E and serum oxidation-related variables is apolipoprotein E phenotype dependent.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Longevity is moderately heritable in a sample of Danish twins born 1870-1880.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Genetic associations with human longevity at the APOE and ACE loci.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E synthesis in peripheral tissues of nonhuman primates.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Genetic influence on human lifespan and longevity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E and longevity among Han Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Comparison of astrocytic and myocytic metabolic dysregulation in apolipoprotein E deficient and human apolipoprotein E transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E protects against bacterial lipopolysaccharide-induced lethality. A new therapeutic approach to treat gram-negative sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Impact of apolipoprotein E genotype and dietary quercetin on paraoxonase 1 status in apoE3 and apoE4 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Influence of the apolipoprotein E epsilon4 allele on human embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Time course of response to estradiol replacement in ovariectomized mice: brain apolipoprotein E and synaptophysin transiently increase and glial fibrillary acidic protein is suppressed

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

APOE Genotype and an ApoE-mimetic Peptide Modify the Systemic and Central Nervous System Inflammatory Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts).

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Apolipoprotein E (APOE) genotype regulates body weight and fatty acid utilization-Studies in gene-targeted replacement mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Linking ecological immunology and evolutionary medicine: the case for apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2FS12944-016-0288-2

Neurotoxicity from innate immune response is greatest with targeted replacement of E4 allele of apolipoprotein E gene and is mediated by microglial p38MAPK.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Microglial activation in Alzheimer disease: Association with APOE genotype.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4960866

Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study

28 November 2018

1 reference

12 December 2020

Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype

1 reference

12 December 2020

Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice

1 reference

12 December 2020

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms

1 reference

12 December 2020

Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study

1 reference

12 December 2020

Apolipoprotein E (apoE) polymorphism and its influence on ApoE concentrations in the cerebrospinal fluid in Finnish patients with Alzheimer's disease

1 reference

12 December 2020

New insights and current concepts of the oxidative stress theory of aging

1 reference

12 December 2020

Apolipoprotein E polymorphism distribution in an elderly Brazilian population: the Bambuí Health and Aging Study

1 reference

12 December 2020

Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene"

1 reference

12 December 2020

A study of French centenarians: are ACE and APOE associated with longevity?

1 reference

12 December 2020

Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo

1 reference

12 December 2020

Macrophage, But Not Systemic, Apolipoprotein E Is Necessary for Macrophage Reverse Cholesterol Transport In Vivo

1 reference

12 December 2020

Apolipoprotein E knock-out mice are highly susceptible to endotoxemia and Klebsiella pneumoniae infection

1 reference

12 December 2020

Apolipoprotein E isoform-specific effects on cytokine and nitric oxide production from mouse Schwann cells after inflammatory stimulation

1 reference

12 December 2020

10.1186/S12944-016-0288-2

Identifiers

DOI

1 reference

Dimensions Publication ID

4423438

1004434572

0 references

4423438

1 reference

1 reference

1 reference