Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease (Q36061394)

11 August 2017

Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease (English)

1 reference

11 August 2017

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1

Carl Frieden

1 reference

11 August 2017

Kanchan Garai

2

1 reference

PMCID

3384159

11 August 2017

language of work or name

English

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publication date

21 May 2012

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Proceedings of the National Academy of Sciences of the United States of America

11 August 2017

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11 August 2017

109

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11 August 2017

23

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11 August 2017

8913-8918

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Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry determine the interface and dynamics of apolipoprotein E oligomerization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Mass spectrometry-based protein footprinting characterizes the structures of oligomeric apolipoprotein E2, E3, and E4.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Apolipoprotein E in Alzheimer's disease and other neurological disorders

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

The role of apolipoprotein E in Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Alzheimer's disease genetics current status and future perspectives

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Apolipoprotein E structure: insights into function.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Interaction of the N-terminal domain of apolipoprotein E4 with heparin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Dissociation of apolipoprotein E oligomers to monomer is required for high-affinity binding to phospholipid vesicles

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

The association−dissociation behavior of the ApoE proteins: kinetic and equilibrium studies

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Relative efficacies of amyloid beta peptide (A beta) binding proteins in A beta aggregation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

APOE genotype in cerebrovascular disease and vascular dementia.

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

A monomeric, biologically active, full-length human apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

A unified scheme for initiation and conformational adaptation of human apolipoprotein E N-terminal domain upon lipoprotein binding and for receptor binding activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

The structure of human apolipoprotein E2, E3 and E4 in solution 1. Tertiary and quaternary structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Effect of carboxyl-terminal truncation on structure and lipid interaction of human apolipoprotein E4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Mapping ApoE/Aβ binding regions to guide inhibitor discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1207022109

Structural differences between apolipoprotein E3 and E4 as measured by (19)F NMR.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3384159

An ApoE-Abeta inhibition complex in Abeta fibril extension

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22615372

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1207022109

1 reference

11 August 2017

0 references

1 reference

11 August 2017

1 reference

PMCID

3384159