Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein (Q35974993)

11 August 2017

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein (English)

1 reference

11 August 2017

Ioannis Papaioannou

1

1 reference

PMCID

3356902

11 August 2017

J Paul Simons

series ordinal

2

1 reference

PMCID

3356902

11 August 2017

James S Owen

series ordinal

3

1 reference

11 August 2017

7 May 2012

1 reference

Cardiology Research and Practice

11 August 2017

1 reference

11 August 2017

2012

1 reference

11 August 2017

148796

1 reference

Creative Commons Attribution 3.0 Unported

11 August 2017

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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2 October 2017

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Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells

2 October 2017

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Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors.

2 October 2017

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A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

2 October 2017

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Cross-talk between apolipoprotein E and cytokines

2 October 2017

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High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

2 October 2017

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Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

2 October 2017

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Liver engraftment potential of hepatic cells derived from patient-specific induced pluripotent stem cells

2 October 2017

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In vivo genome editing restores haemostasis in a mouse model of haemophilia

2 October 2017

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Zinc-finger nucleases for somatic gene therapy: the next frontier

2 October 2017

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Advances in farm animal transgenesis.

2 October 2017

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Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs

2 October 2017

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Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people

2 October 2017

1 reference

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Unexpected roles for PCSK9 in lipid metabolism

2 October 2017

1 reference

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Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

2 October 2017

1 reference

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Ex vivo gene transfer and correction for cell-based therapies

2 October 2017

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Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

2 October 2017

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An update on targeted gene repair in mammalian cells: methods and mechanisms

2 October 2017

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Novel HDL-directed pharmacotherapeutic strategies

2 October 2017

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Mipomersen, an antisense apolipoprotein B synthesis inhibitor

2 October 2017

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PCSK9: an emerging target for treatment of hypercholesterolemia

2 October 2017

1 reference

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Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy

2 October 2017

1 reference

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Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

2 October 2017

1 reference

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Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects.

2 October 2017

1 reference

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Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis.

2 October 2017

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Targeting DNA double-strand breaks with TAL effector nucleases

2 October 2017

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Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle.

2 October 2017

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Engineering of human pluripotent stem cells by AAV-mediated gene targeting

2 October 2017

1 reference

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Generation of functional human hepatic endoderm from human induced pluripotent stem cells

2 October 2017

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Gene targeting in human pluripotent stem cells with adeno-associated virus vectors

2 October 2017

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Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector

2 October 2017

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Enhancing cardiovascular disease risk reduction: raising high-density lipoprotein levels.

2 October 2017

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Update on strategies to increase HDL quantity and function

2 October 2017

1 reference

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Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels

2 October 2017

1 reference

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Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Progress and prospects: zinc-finger nucleases as gene therapy agents

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Human cholesterol metabolism and therapeutic molecules

2 October 2017

1 reference

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Using homologous recombination to manipulate the genome of human somatic cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Association of apolipoprotein E genotypes with lipid levels and coronary risk

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apoprotein E isoform-dependent expression and secretion of pro-inflammatory cytokines TNF-alpha and IL-6 in macrophages

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Impaired secretion of apolipoprotein E2 from macrophages

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vector

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Homologous recombination is required for AAV-mediated gene targeting

2 October 2017

1 reference

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Apolipoprotein E structure: insights into function.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

LDL composition in E2/2 subjects and LDL distribution by Apo E genotype in type 1 diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E and coronary disease: a puzzling paradox

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

ApoE plasma levels and risk of cardiovascular mortality in old age

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Does apolipoprotein E genotype influence the risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage? Systematic review and meta-analyses of 31 studies among 5961 cases and 17,965 controls.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein-mediated pathways of lipid antigen presentation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Mammalian gene targeting with designed zinc finger nucleases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Physical incorporation of a single-stranded oligodeoxynucleotide during targeted repair of a human chromosomal locus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Understanding hyperlipidemia and atherosclerosis: lessons from genetically modified apoe and ldlr mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Inflammation, atherosclerosis, and coronary artery disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

The key role of apolipoprotein E in atherosclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Gene therapy progress and prospects: targeted gene repair

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

HDL as a target in the treatment of atherosclerotic cardiovascular disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Distinct signaling mechanisms for apoE inhibition of cell migration and proliferation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Gene therapy with novel adeno-associated virus vectors substantially diminishes atherosclerosis in a murine model of familial hypercholesterolemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Secreted apolipoprotein E reduces macrophage-mediated LDL oxidation in an isoform-dependent way.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Chimeric nucleases stimulate gene targeting in human cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Gene correction of the apolipoprotein (Apo) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

A plausible mechanism for gene correction by chimeric oligonucleotides

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia). Questions, quandaries, and paradoxes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Correction of the UDP-glucuronosyltransferase gene defect in the gunn rat model of crigler-najjar syndrome type I with a chimeric oligonucleotide

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Liver-directed gene transfer and prolonged expression of three major human ApoE isoforms in ApoE-deficient mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Genetic manipulation of genomes with rare-cutting endonucleases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

High frequency targeting of genes to specific sites in the mammalian genome

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Transformation of yeast with synthetic oligonucleotides

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

The prevention of cardiovascular disease worldwide: whose task and WHO's task?

11 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

AAV gene therapy as a means to increase apolipoprotein (Apo) A-I and high-density lipoprotein-cholesterol levels: correction of murine ApoA-I deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E and atherosclerosis: beyond lipid effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

The receptor binding domain of apolipoprotein E is responsible for its antioxidant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E suppresses the type I inflammatory response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

A novel endothelial cell-based gene therapy platform for the in vivo delivery of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Effect of macrophage-derived apolipoprotein E on established atherosclerosis in apolipoprotein E-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Gene transfer into skeletal muscle using novel AAV serotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Subphysiologic apolipoprotein E (ApoE) plasma levels inhibit neointimal formation after arterial injury in ApoE-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Validation of oligonucleotide-mediated gene editing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Use of internally nuclease-protected single-strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Antibody phenotyping test for the human apolipoprotein E2 isoform

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3356902

Apolipoprotein E Alleles and Risk of Coronary Disease

24 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F148796

Nucleotide exchange in genomic DNA of rat hepatocytes using RNA/DNA oligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor

21 January 2018

1 reference

12 December 2020

Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice

1 reference

12 December 2020

Targeted gene conversion in a mammalian CD34+-enriched cell population using a chimeric RNA/DNA oligonucleotide

1 reference

12 December 2020

Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide

1 reference

12 December 2020

Apolipoprotein E-deficient mice have an impaired immune response to Klebsiella pneumoniae

1 reference

12 December 2020

Apolipoprotein A-I therapy promise, challenges, and disappointment

1 reference

12 December 2020

ApoE in atherosclerosis : a protein with multiple hats

1 reference

12 December 2020

Chimeraplasty validation

1 reference

12 December 2020

Gene-editing nucleases

1 reference

12 December 2020

Recombinant DNA technique and sickle cell anemia research

1 reference

12 December 2020

Overexpression of apolipoprotein E prevents development of diabetic hyperlipidemia in transgenic mice

1 reference

12 December 2020

Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components

1 reference

12 December 2020

On target? Tracing zinc-finger-nuclease specificity

1 reference

12 December 2020

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

1 reference

12 December 2020

Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo

1 reference

12 December 2020

Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide

1 reference

12 December 2020

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

1 reference

12 December 2020

In vivo site-directed mutagenesis of the factor IX gene by chimeric RNA/DNA oligonucleotides

1 reference

12 December 2020

Commentary on the paper by Gustavsson et al. entitled ‘Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women’

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/148796

1 reference

11 August 2017

1 reference

11 August 2017

1 reference

PMCID

3356902