ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice (Q30539979)

24 September 2017

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice (English)

1 reference

24 September 2017

0 references

Ori Liraz

1

1 reference

24 September 2017

Anat Boehm-Cagan

series ordinal

2

1 reference

24 September 2017

Daniel M Michaelson

series ordinal

3

1 reference

24 September 2017

17 May 2013

1 reference

Molecular Neurodegeneration

24 September 2017

1 reference

24 September 2017

8

1 reference

24 September 2017

16

1 reference

https://scigraph.springernature.com/pub.10.1186/1750-1326-8-16

24 September 2017

0 references

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Functional analysis of APOE locus genetic variation implicates regional enhancers in the regulation of both TOMM40 and APOE.

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Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

20 June 2018

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ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

20 June 2018

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Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

20 June 2018

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Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2.

20 June 2018

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice

20 June 2018

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Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration

20 June 2018

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Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene

20 June 2018

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ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

20 June 2018

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Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype

20 June 2018

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Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

20 June 2018

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20 June 2018

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Pre-clinical detection of Alzheimer's disease using FDG-PET, with or without amyloid imaging

20 June 2018

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Possible role of tau in mediating pathological effects of apoE4 in vivo prior to and following activation of the amyloid cascade

20 June 2018

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The clinical use of structural MRI in Alzheimer disease

20 June 2018

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Positive effects of cholinergic stimulation favor young APOE epsilon4 carriers

20 June 2018

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ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo.

20 June 2018

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Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

20 June 2018

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The role of apolipoprotein E in Alzheimer's disease

20 June 2018

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Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

20 June 2018

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Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease

20 June 2018

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ApoE promotes the proteolytic degradation of Abeta

20 June 2018

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Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits

20 June 2018

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A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

20 June 2018

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Neuronal death: where does the end begin?

20 June 2018

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Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid

20 June 2018

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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

20 June 2018

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Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation

20 June 2018

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Has the amyloid cascade hypothesis for Alzheimer's disease been proved?

20 June 2018

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Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

20 June 2018

1 reference

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Mitochondria take center stage in aging and neurodegeneration

20 June 2018

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20 June 2018

1 reference

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Amyloid accumulation and pathogensis of Alzheimer's disease: significance of monomeric, oligomeric and fibrillar Abeta.

20 June 2018

1 reference

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Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc

20 June 2018

1 reference

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In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology

20 June 2018

1 reference

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Regional brain atrophy rate predicts future cognitive decline: 6-year longitudinal MR imaging study of normal aging

20 June 2018

1 reference

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Apolipoprotein E and β‐amyloid (1–42) regulation of glycogen synthase kinase‐3β

20 June 2018

1 reference

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APP processing and synaptic function

20 June 2018

1 reference

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Neurodegenerative tauopathies

20 June 2018

1 reference

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Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

20 June 2018

1 reference

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

20 June 2018

1 reference

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Alzheimer's disease: genes, proteins, and therapy

20 June 2018

1 reference

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Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

20 June 2018

1 reference

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Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice

20 June 2018

1 reference

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Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

20 June 2018

1 reference

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Cognitive function and apolipoprotein E in very old adults: findings from the Nun Study.

20 June 2018

1 reference

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Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

20 June 2018

1 reference

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Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

20 June 2018

1 reference

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Mechanisms of synaptic pathology in Alzheimer's disease.

20 June 2018

1 reference

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Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

20 June 2018

1 reference

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Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Apolipoprotein E alleles as risk factors in Alzheimer's disease

20 June 2018

1 reference

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Developmental expression of tau proteins in the chicken and rat brain: rapid down-regulation of a paired helical filament epitope in the rat cerebral cortex coincides with the transition from immature to adult tau isoforms.

20 June 2018

1 reference

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Regulation of microtubule dynamics by microtubule-associated protein expression and phosphorylation during neuronal development.

20 June 2018

1 reference

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Molecular dissection of the paired helical filament

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Amyloid plaque core protein in Alzheimer disease and Down syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Quantitative assessment of cortical synaptic density in Alzheimer's disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Neuropathological stageing of Alzheimer-related changes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Changes in PKC gamma immunoreactivity in mouse hippocampus induced by spatial discrimination learning.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde".

20 June 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Accelerated hippocampal atrophy in Alzheimer's disease with apolipoprotein E epsilon4 allele.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

ApoE4-dependent Abeta-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

The effects of apolipoproteins E3 and E4 on the transforming growth factor-β system in targeted replacement mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Quantitative analysis of GAD65 and GAD67 immunoreactivities in somata of GABAergic neurons in the mouse hippocampus proper (CA1 and CA3 regions), with special reference to parvalbumin-containing neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Spatial navigation in the Morris water maze: working and long lasting reference memories.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

ApoE isoform affects LTP in human targeted replacement mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Phosphorylation state of tau in the hippocampus of apolipoprotein E4 and E3 knock-in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.

21 January 2018

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https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Differential phosphorylation of tau proteins during kitten brain development and Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1750-1326-8-16

ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Microglial activation in Alzheimer disease: Association with APOE genotype.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3659080

[Amyloid PET in Alzheimer research]

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23684315

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23684315

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The APOE ɛ4 allele modulates brain white matter integrity in healthy adults

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23684315

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1750-1326-8-16

1 reference

Dimensions Publication ID

24 September 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1750-1326-8-16

1 reference

24 September 2017

1 reference