Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks (Q26740559)

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20 March 2020

review article

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9 September 2020

Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks (English)

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20 March 2020

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20 March 2020

Marco G. Alves

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2

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20 March 2020

Pedro F. Oliveira

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20 March 2020

Branca M. Silva

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publication date

27 July 2016

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20 March 2020

9 September 2020

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20 March 2020

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issue

8

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Creative Commons Attribution

20 March 2020

copyright license

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9 September 2020

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21 January 2018

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https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee consumption and cognitive function among older adults

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Smoking, alcohol, and coffee consumption preceding Parkinson's disease: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Association of coffee and caffeine intake with the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine and risk of Parkinson's disease in a large cohort of men and women

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Dose-response meta-analysis on coffee, tea and caffeine consumption with risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Association between caffeine intake and age at onset in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Methylxanthine treatment for apnea in preterm infants

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine citrate: a review of its use in apnoea of prematurity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Current options in the management of apnea of prematurity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine impact on neonatal morbidities

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Use of methylxanthine therapies for the treatment and prevention of apnea of prematurity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Neonatal breathing control mediated via the central chemoreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Adenosinergic modulation of respiratory neurones in the neonatal rat brainstem in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Methylxanthine reversal of opioid-induced respiratory depression in the neonatal rat: mechanism and location of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Theophylline in chronic obstructive pulmonary disease: new horizons

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

21 January 2018

Theophylline for COPD.

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Theobromine inhibits sensory nerve activation and cough

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effects of caffeine on microcirculation of the human ocular fundus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effects of tea and coffee on cardiovascular disease risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effect of cocoa and theobromine consumption on serum HDL-cholesterol concentrations: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

The effect of theophylline ethylene diamine on renal function in control subjects and in patients with congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Methylxanthines and the Kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effect of theophylline and other drugs on rabbit renal cyclic nucleotide phosphodiesterase, 5′-nucleotidase and adenosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeinated and caffeine-free beverages and risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine, diabetes, cognition, and dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee to reduce risk of type 2 diabetes?: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee consumption and risk of type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee consumption and risk of type 2 diabetes: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Differential effects of coffee on the risk of type 2 diabetes according to meal consumption in a French cohort of women: the E3N/EPIC cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: a systematic review and a dose-response meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee and tea consumption and risk of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Tea consumption and risk of type 2 diabetes: a dose-response meta-analysis of cohort studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effects of bioactive constituents in functional cocoa products on cardiovascular health in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Roles of cAMP signalling in insulin granule exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Tadalafil inhibits the cAMP stimulated glucose output in the rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Topical applications of caffeine or (-)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine suppresses metastasis in a transgenic mouse model: a prototype molecule for prophylaxis of metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Potentiation of Lipid Peroxidation in B16F10 and B16F1 Melanoma Cells by Caffeine, a Methylxanthine Derivative: Relationship to Intracellular Glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine inhibits cell proliferation by G0/G1 phase arrest in JB6 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Theophylline as a therapy for chronic lymphocytic leukemia: a case report and review of literature

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Phosphodiesterase inhibitors as anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effect of methylxanthine derivatives on doxorubicin transport and antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effect of chemotherapy combined with caffeine for osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

1-Methylxanthine enhances the radiosensitivity of tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

The enigmatic effects of caffeine in cell cycle and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Modulation of cellular response to anticancer treatment by caffeine: inhibition of cell cycle checkpoints, DNA repair and more

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile: relevance for male fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Regulation of sperm flagellar motility by calcium and cAMP-dependent phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

White tea as a promising antioxidant medium additive for sperm storage at room temperature: a comparative study with green tea.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Improved fertility in gilts and sows after artificial insemination of frozen-thawed boar semen by supplementation of semen extender with caffeine and CaCl2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Oral application of 1,7-dimethylxanthine (paraxanthine) attenuates the formation of experimental cholestatic liver fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Increased caffeine consumption is associated with reduced hepatic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Theobromine inhibits uric acid crystallization. A potential application in the treatment of uric acid nephrolithiasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effects of 7-methylxanthine on the sclera in form deprivation myopia in guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Modifications of maternal caffeine intake for improving pregnancy outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine use during pregnancy and child outcome: a 7-year prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Effect of reducing caffeine intake on birth weight and length of gestation: randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Maternal caffeine intake and risk of selected birth defects in the National Birth Defects Prevention Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Maternal caffeine consumption and risk of neural tube defects

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Maternal caffeine consumption and small for gestational age births: results from a population-based case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Maternal caffeine consumption and risk of congenital limb deficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

21 January 2018

Caffeine in pregnancy

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine: cognitive and physical performance enhancer or psychoactive drug?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Genetic factors modulating the response to stimulant drugs in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Association between A2a receptor gene polymorphisms and caffeine-induced anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Caffeine—Not just a stimulant

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Safety issues associated with commercially available energy drinks.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Fatal caffeine intoxication: a series of eight cases from 1999 to 2009.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Methylxanthines: toxicity to humans. 2. Caffeine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee-induced Hypokalaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Psychopharmacology of theobromine in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Recent advances in caffeine and theobromine toxicities: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

The diuretic action of 8-cyclopentyl-1,3-dipropylxanthine, a selective A1 adenosine receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Green tea: A promising anticancer agent for renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Simultaneous Determination of Caffeine, Ergotamine, and Metamizol in Solid Pharmaceutical Formulation by HPTLC-UV-FLD with Mass Confirmation by Online HPTLC-ESI-MS

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Stimulation of calcium release by caffeine analogs in pheochromocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Quantitative study on the non-covalent interactions between ATP and caffeine, theophylline and theobromine in aqueous solution

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

The absolute bioavailability of caffeine in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Prospective study of coffee consumption and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Coffee Consumption and Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Regular consumption of cocoa powder with milk increases HDL cholesterol and reduces oxidized LDL levels in subjects at high-risk of cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

21 January 2018

1 reference

12 December 2020

Salivary clearance and urinary metabolic pattern of caffeine in healthy children and in pediatric patients with hepatocellular diseases

1 reference

12 December 2020

Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist

1 reference

12 December 2020

Caffeine content of beverages as consumed

1 reference

12 December 2020

Caffeine alters A2A adenosine receptors and their function in human platelets

1 reference

12 December 2020

Caffeine in plasma and saliva by a radioimmunoassay procedure

1 reference

12 December 2020

Therapeutic efficacy of theophylline in chronic lymphocytic leukemia

1 reference

12 December 2020

Potentiation of cADPR-induced Ca(2+)-release by methylxanthine analogues

1 reference

12 December 2020

HPLC determination of catechins and caffeine in tea. Differentiation of green, black and instant teas

1 reference

12 December 2020

Adenosine receptor antagonism causes inhibition of angiogenic activity of human ovarian cancer cells.

1 reference

12 December 2020

Comparison of caffeine and theophylline ingestion: exercise metabolism and endurance.

1 reference

12 December 2020

Liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine

1 reference

12 December 2020

Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.

1 reference

12 December 2020

The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy

1 reference

12 December 2020

Effect of Caffeine, a xanthine derivative, in the inhibition of experimental lung metastasis induced by B16F10 melanoma cells.

1 reference

12 December 2020

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

1 reference

12 December 2020

Adenosine receptor ligands as potential therapeutics in asthma

1 reference

12 December 2020

8-Aryl xanthines potent inhibitors of phosphodiesterase 5

1 reference

12 December 2020

Antioxidant and prooxidant properties of caffeine, theobromine and xanthine.

1 reference

12 December 2020

Selective bronchodilators from 1-(5'-oxohexyl)xanthines

1 reference

12 December 2020

Reevaluation of the usefulness of theobromine calcium gluconate for the management of congestive heart failure and anginal syndrome

1 reference

12 December 2020

Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine

1 reference

12 December 2020

Caffeine increases maximal anaerobic power and blood lactate concentration

1 reference

12 December 2020

Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?

1 reference

12 December 2020

Determination of adenine, caffeine, theophylline and theobromine by HPLC with amperometric detection

1 reference

12 December 2020

G2 checkpoint abrogators as anticancer drugs

1 reference

12 December 2020

Multiple effects of theobromine on fetus development and postnatal status of the immune system.

1 reference

12 December 2020

The Action of Caffeine on X-Irradiated HeLa Cells: III. Enhancement of X-Ray-Induced Killing during G 2 Arrest

1 reference

12 December 2020

Caffeine-potentiated chemotherapy for metastatic carcinoma and lymphoma of bone and soft tissue.

1 reference

12 December 2020

Determination of substituted purines in body fluids by micellar electrokinetic capillary chromatography with direct sample injection

1 reference

12 December 2020

Changes in caffeine intake and long-term weight change in men and women

1 reference

12 December 2020

Differential effect of selected methylxanthine derivatives on radiosensitization of lung carcinoma cells

1 reference

12 December 2020

Coffee consumption and risk of total and cardiovascular mortality among patients with type 2 diabetes

1 reference

12 December 2020

Methylxanthines block antigen-induced responses in RBL-2H3 cells independently of adenosine receptors or cyclic AMP: evidence for inhibition of antigen binding to IgE

1 reference

12 December 2020

Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans

1 reference

12 December 2020

Maternal caffeine consumption and risk of cardiovascular malformations

1 reference

12 December 2020

[Caffeine: a nutrient, a drug or a drug of abuse]

1 reference

12 December 2020

Performance and metabolic responses to a high caffeine dose during prolonged exercise

1 reference

12 December 2020

Caffeine dose-dependently potentiates the antitumor effect of cisplatin on osteosarcomas.

1 reference

12 December 2020

Caffeine and theophylline as adenosine receptor antagonists in humans

1 reference

12 December 2020

Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study

1 reference

12 December 2020

Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice

1 reference

12 December 2020

Caffeine suppresses amyloid-beta levels in plasma and brain of Alzheimer's disease transgenic mice

1 reference

12 December 2020

Caffeine exposure and the risk of Parkinson's disease: a systematic review and meta-analysis of observational studies

1 reference

12 December 2020

Caffeine and coffee as therapeutics against Alzheimer's disease

1 reference

12 December 2020

The lipotropic activity of caffeine, theobromine and theophylline

1 reference

12 December 2020

SPECT assessment of brain activation induced by caffeine: no effect on areas involved in dependence.

1 reference

12 December 2020

Distribution, biosynthesis and catabolism of methylxanthines in plants

1 reference

12 December 2020

Pharmacokinetics and Metabolism of Natural Methylxanthines in Animal and Man

1 reference

12 December 2020

Inhibition of cyclic nucleotide phosphodiesterases by methylxanthines and related compounds

1 reference

12 December 2020

Theobromine and the Pharmacology of Cocoa

1 reference

12 December 2020

Impacts of methylxanthines and adenosine receptors on neurodegeneration: human and experimental studies.

1 reference

12 December 2020

The Cardiovascular Effects of Methylxanthines

1 reference

12 December 2020

Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy: a case report and review of the literature.

1 reference

12 December 2020

Methylxanthine treatment for apnoea in preterm infants

1 reference

12 December 2020

Caffeine and human cerebral blood flow: a positron emission tomography study

1 reference

12 December 2020

Is Caffeine a Good Scavenger of Oxygenated Free Radicals?

1 reference

12 December 2020

Espresso coffees, caffeine and chlorogenic acid intake: potential health implications

1 reference

12 December 2020

The effects of prenatal exposure to methylxanthines.

1 reference

12 December 2020

Influence of caffeine administered during pregnancy on the early differentiation of fetal rat ovaries and testes

1 reference

12 December 2020

Development and validation of a rapid ultra high pressure liquid chromatographic method for the determination of methylxanthines in herbal infusions

1 reference

12 December 2020

Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome

1 reference

12 December 2020

Novel 8-heterocyclyl xanthine derivatives in drug development - an update

1 reference

12 December 2020

1 reference

12 December 2020

Xanthine effects on renal proximal tubular function and cyclic AMP metabolism

1 reference

12 December 2020

Caffeine as an analgesic adjuvant for acute pain in adults

1 reference

12 December 2020

Chronic caffeine or theophylline exposure reduces gamma-aminobutyric acid/benzodiazepine receptor site interactions

1 reference

12 December 2020

Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by caffeine and related compounds

1 reference

12 December 2020

On the mechanism of action of theophylline and caffeine.

1 reference

12 December 2020

Cytotoxic, cell cycle, and chromosomal effects of methylxanthines in human tumor cells treated with alkylating agents

1 reference

12 December 2020

In vivo and in vitro enhanced antitumor effects by pentoxifylline in human cancer cells treated with thiotepa

1 reference

12 December 2020

Structure-activity relationship in N3-alkyl-xanthine derivatives

1 reference

12 December 2020

Rapid high-performance liquid chromatography assay for salivary and serum caffeine following an oral load. An indicator of liver function

1 reference

12 December 2020

Characterization of adenosine-induced respiratory depression in the preterm rabbit

1 reference

12 December 2020

Antagonism by theophylline of respiratory inhibition induced by adenosine

1 reference

12 December 2020

Testicular atrophy and impaired spermatogenesis in rats fed high levels of the methylxanthines caffeine, theobromine, or theophylline

1 reference

12 December 2020

A comparison of the effects of lipolytic and antilipolytic agents on adenosine 3',5'-monophosphate levels in adipose cells as determined by prior labeling with adenine-8-14C.

1 reference

12 December 2020

Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity

1 reference

12 December 2020

Mobilization of fatty acids in genetically obese rats

1 reference

12 December 2020

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices

1 reference

12 December 2020

[Biological effectiveness of methyl xanthines in cocoa products]

1 reference

12 December 2020

Coffee, Tea, or Cocoa. A trio of experiments including the isolation of theobromine from cocoa

1 reference

12 December 2020

Characterization of basal and methylxanthine-stimulated Ca2+ transport in abalone spermatozoa

1 reference

12 December 2020

Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts

1 reference

12 December 2020

Regulation of Protein Phosphorylation and Motility of Sperm by Cyclic Adenosine Monophosphate and Calcium

1 reference

12 December 2020

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1 reference

12 December 2020

Caffeine as an analgesic adjuvant

1 reference

12 December 2020

Comparative toxicities of dietary caffeine and theobromine in the rat

1 reference

12 December 2020

The bronchodilator effects and pharmacokinetics of caffeine in asthma

1 reference

12 December 2020

Gas chromatographic-mass spectrometric quantitation of theophylline and its metabolites in biological fluids

1 reference

12 December 2020

Determination of plasma theophylline by straight-phase high-performance liquid chromatography: Elimination of interfering caffeine metabolites

1 reference

12 December 2020

Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice

1 reference

12 December 2020

Agonist-activated, ryanodine-sensitive, IP3-insensitive Ca2+ release channels in longitudinal muscle of intestine

1 reference

12 December 2020

Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord

1 reference

12 December 2020

Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants

1 reference

12 December 2020

Effects of a milk chocolate bar per day substituted for a high-carbohydrate snack in young men on an NCEP/AHA Step 1 Diet

1 reference

12 December 2020

Theophylline suppresses human alveolar macrophage respiratory burst through phosphodiesterase inhibition

1 reference

12 December 2020

Metabolic catecholamine, and endurance responses to caffeine during intense exercise

1 reference

12 December 2020

Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses

1 reference

12 December 2020

Determination of caffeine and its metabolites by micellar electrokinetic capillary electrophoresis

1 reference

12 December 2020

Structure-activity relationship of xanthines and skeletal muscle ryanodine receptor/Ca2+ release channel

1 reference

12 December 2020

Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea.

1 reference

12 December 2020

The influence of theobromine on angiogenic activity and proangiogenic cytokines production of human ovarian cancer cells

1 reference

12 December 2020

Analysis of urinary caffeine metabolites to assess biotransformation enzyme activities by reversed-phase high-performance liquid chromatography.

1 reference

12 December 2020

Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance

1 reference

12 December 2020

Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent.

1 reference

12 December 2020

More sensitive high-pressure liquid-chromatographic determiantion of theophylline in serum.

1 reference

12 December 2020

Low-dose theophylline increases urine output in diuretic-dependent critically ill children

1 reference

12 December 2020

Combined effect of CDDP and caffeine against human gastric cell line in vivo

1 reference

12 December 2020

Caffeine in Citrus flowers

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

7 January 2021

inferred from DOI database lookup

HPLC Determination of Caffeine and Theobromine in Coffee, Tea, and Instant Hot Cocoa Mixes

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21080974

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3390/MOLECULES21080974

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472311%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27472311%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

27472311

1 reference