Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease (Q42437833)

31 October 2017

Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease (English)

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31 October 2017

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3

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31 October 2017

Nélio Gonçalves

1

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PubMed ID

23625556

31 October 2017

Ana T Simões

series ordinal

2

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PubMed ID

23625556

31 October 2017

Luís Pereira de Almeida

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4

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31 October 2017

26 April 2013

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31 October 2017

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31 October 2017

73

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31 October 2017

5

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31 October 2017

655-666

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The CAG/polyglutamine tract diseases: gene products and molecular pathogenesis

31 October 2017

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Spinocerebellar ataxia 3 and Machado-Joseph disease: clinical, molecular, and neuropathological features.

21 January 2018

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CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

21 January 2018

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Spinocerebellar ataxia type 3 phenotypically resembling parkinson disease in a black family

21 January 2018

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Pathways to motor incoordination: the inherited ataxias

21 January 2018

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Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

21 January 2018

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Dopamine transporter positron emission tomography in spinocerebellar ataxias type 1, 2, 3, and 6.

21 January 2018

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Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

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Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

21 January 2018

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A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

21 January 2018

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YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.

21 January 2018

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Minocycline in phenotypic models of Huntington's disease

21 January 2018

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Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.

21 January 2018

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Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

21 January 2018

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Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

21 January 2018

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Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

21 January 2018

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Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation

21 January 2018

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Adenosine receptors and brain diseases: neuroprotection and neurodegeneration

21 January 2018

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Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease

21 January 2018

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Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.

21 January 2018

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Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice

21 January 2018

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Caffeine, adenosine receptors, and synaptic plasticity

21 January 2018

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Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

21 January 2018

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Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.

21 January 2018

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Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons.

21 January 2018

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A focus on the synapse for neuroprotection in Alzheimer disease and other dementias

21 January 2018

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Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat.

21 January 2018

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Axonal dysfunction in the deep white matter in Machado-Joseph disease

21 January 2018

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Axonal inclusions in spinocerebellar ataxia type 3.

21 January 2018

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Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements

21 January 2018

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Huntington's disease: a synaptopathy?

21 January 2018

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Synaptic vulnerability in neurodegenerative disease

21 January 2018

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Heterogeneous intracellular localization and expression of ataxin-3.

21 January 2018

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Longitudinal study on MRI intensity changes of Machado-Joseph disease: correlation between MRI findings and neuropathological changes.

21 January 2018

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Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.

21 January 2018

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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

21 January 2018

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Machado-Joseph disease gene product identified in lymphocytes and brain.

21 January 2018

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An update on the mechanisms of the psychostimulant effects of caffeine.

21 January 2018

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Targeting adenosine A2A receptors in Parkinson's disease

21 January 2018

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Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway

21 January 2018

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Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons.

21 January 2018

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Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes

21 January 2018

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Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration

21 January 2018

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Adenosine A2A receptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms.

21 January 2018

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Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

21 January 2018

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Adenosine A2A receptors and basal ganglia physiology

21 January 2018

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Neuroprotection by adenosine in the brain: From A(1) receptor activation to A (2A) receptor blockade

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

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Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic

21 January 2018

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Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

21 January 2018

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The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

21 January 2018

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Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis

21 January 2018

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Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

21 January 2018

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Protein homeostasis and synaptic plasticity

21 January 2018

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Ubiquitin-dependent regulation of the synapse.

21 January 2018

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A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing

21 January 2018

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Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons

21 January 2018

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

21 January 2018

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The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor

21 January 2018

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The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system

21 January 2018

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Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses

21 January 2018

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Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

21 January 2018

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A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors

21 January 2018

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The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/ANA.23866

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31 October 2017

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PubMed ID

23625556